{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T06:53:18Z","timestamp":1794293598778,"version":"4.9.0"},"reference-count":60,"publisher":"Society for Neuroscience","issue":"42","license":[{"start":{"date-parts":[[2006,4,19]],"date-time":"2006-04-19T00:00:00Z","timestamp":1145404800000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2005,10,19]]},"abstract":"<jats:p>\n                    Pax6 is a transcription factor with key functional roles in the developing brain. Pax6 promotes neuronal differentiation via transcriptional regulation of the\n                    <jats:italic>Neurogenin2<\/jats:italic>\n                    (\n                    <jats:italic>Ngn2<\/jats:italic>\n                    ) gene, although Pax6 expression appears in proliferating neuroepithelial cells before the onset of neurogenesis. Here, we identified\n                    <jats:italic>Fabp7<\/jats:italic>\n                    (\n                    <jats:italic>BLBP\/B-FABP<\/jats:italic>\n                    ), a member of the fatty acid-binding protein (FABP) family, as a downregulated gene in the embryonic brain of\n                    <jats:italic>Pax6<\/jats:italic>\n                    mutant rat (\n                    <jats:italic>\n                      rSey\n                      <jats:sup>2<\/jats:sup>\n                      \/rSey\n                      <jats:sup>2<\/jats:sup>\n                    <\/jats:italic>\n                    ) by microarray analysis. Marked reduction of\n                    <jats:italic>Fabp7<\/jats:italic>\n                    expression was confirmed by quantitative PCR. Spatiotemporal expression patterns of\n                    <jats:italic>Fabp7<\/jats:italic>\n                    in the wild-type rat embryos from embryonic day 10.5 (E10.5) to E14.5 were similar to those of\n                    <jats:italic>Pax6<\/jats:italic>\n                    , and expression of\n                    <jats:italic>Fabp7<\/jats:italic>\n                    was undetectable in the\n                    <jats:italic>\n                      rSey\n                      <jats:sup>2<\/jats:sup>\n                      \/rSey\n                      <jats:sup>2<\/jats:sup>\n                    <\/jats:italic>\n                    cortex. The expression pattern of\n                    <jats:italic>Fabp7<\/jats:italic>\n                    in the wild-type mouse embryo at E10.5 (corresponding to E12.5 rat) was different from that in the rat embryo, and no change of expression was observed in the\n                    <jats:italic>Sey\/Sey<\/jats:italic>\n                    mouse embryo. Overexpression of exogenous\n                    <jats:italic>Pax6<\/jats:italic>\n                    mainly induced ectopic expression of\n                    <jats:italic>Fabp7<\/jats:italic>\n                    , rather than of\n                    <jats:italic>Ngn2<\/jats:italic>\n                    , in the early cortical primordium. Interestingly, knocking-down FABP7 function by electroporation of\n                    <jats:italic>Fabp7<\/jats:italic>\n                    small interfering RNA severely curtailed cell proliferation but promoted neuronal differentiation. We conclude that\n                    <jats:italic>Fabp7<\/jats:italic>\n                    is a downstream gene of Pax6 transcription factor in the developing rat cortex and essential for maintenance of neuroepithelial cells during early cortical development.\n                  <\/jats:p>","DOI":"10.1523\/jneurosci.2512-05.2005","type":"journal-article","created":{"date-parts":[[2005,10,20]],"date-time":"2005-10-20T09:36:50Z","timestamp":1129801010000},"page":"9752-9761","source":"Crossref","is-referenced-by-count":168,"title":["Role of\n                    <i>Fabp7<\/i>\n                    , a Downstream Gene of Pax6, in the Maintenance of Neuroepithelial Cells during Early Embryonic Development of the Rat 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