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Here, we investigate patterns of spontaneous neuronal activity in mouse accessory olfactory bulb mitral cells, the direct neural link between vomeronasal sensory input and limbic output. Both<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>, we identify a subpopulation of mitral cells that exhibit slow stereotypical rhythmic discharge. In intrinsically rhythmogenic neurons, these periodic activity patterns are maintained in absence of fast synaptic drive. The physiological mechanism underlying mitral cell autorhythmicity involves cyclic activation of three interdependent ionic conductances: subthreshold persistent Na<jats:sup>+<\/jats:sup>current, R-type Ca<jats:sup>2+<\/jats:sup>current, and Ca<jats:sup>2+<\/jats:sup>-activated big conductance K<jats:sup>+<\/jats:sup>current. Together, the interplay of these distinct conductances triggers infraslow intrinsic oscillations with remarkable periodicity, a default output state likely to affect sensory processing in limbic circuits.<\/jats:p><jats:p><jats:bold>SIGNIFICANCE STATEMENT<\/jats:bold>We show for the first time that some rodent accessory olfactory bulb mitral cells\u2014the direct link between vomeronasal sensory input and limbic output\u2014are intrinsically rhythmogenic. Driven by \u22653 distinct interdependent ionic conductances, infraslow intrinsic oscillations show remarkable periodicity both<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>. As a novel default state, infraslow autorhythmicity is likely to affect limbic processing of pheromonal information.<\/jats:p>","DOI":"10.1523\/jneurosci.2520-15.2016","type":"journal-article","created":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T18:32:17Z","timestamp":1458153137000},"page":"3127-3144","source":"Crossref","is-referenced-by-count":26,"title":["Interdependent Conductances Drive Infraslow Intrinsic Rhythmogenesis in a Subset of Accessory Olfactory Bulb Projection 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