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Furthermore, whether mGluR5 regulates other developmental processes that occur before or after barrel development is not known. We now show that mGluR5 is present postsynaptically at thalamocortical synapses during barrel formation. In addition,<jats:italic>Mglur5<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup>mice exhibit normal TCA patch formation but reduced cellular segregation in layer 4, indicating a dose-dependent role for mGluR5 in the regulation of pattern formation. Furthermore<jats:italic>Mglur5<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>and<jats:italic>Mglur5<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup>mice display normal cortical arealization, layer formation, and size of PMBSF indicating the defects within S1 do not result from general abnormalities of cortical mapping during earlier stages of development. At P21 layer 4 neurons from<jats:italic>Mglur5<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>and<jats:italic>Mglur5<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup>mice show a significant reduction in spine density but normal dendritic complexity compared with<jats:italic>Mglur5<\/jats:italic><jats:sup>+\/+<\/jats:sup>mice indicating a role in synaptogenesis during cortical development. Finally, mGluR5 regulates pattern formation throughout the trigeminal system of mice as the representation of the AS whiskers in the PrV, VpM, and S1 cortex was disrupted in<jats:italic>Mglur5<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>mice. Together these data indicate a key role for mGluR5 at both early and late stages of neuronal development in the trigeminal system of mice.<\/jats:p>","DOI":"10.1523\/jneurosci.2600-08.2008","type":"journal-article","created":{"date-parts":[[2008,12,3]],"date-time":"2008-12-03T20:16:24Z","timestamp":1228335384000},"page":"13028-13037","source":"Crossref","is-referenced-by-count":64,"title":["mGluR5 Regulates Glutamate-Dependent Development of the Mouse Somatosensory Cortex"],"prefix":"10.1523","volume":"28","author":[{"given":"Lasani S.","family":"Wijetunge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally M.","family":"Till","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Gillingwater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cali 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