{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:48:41Z","timestamp":1770752921592,"version":"3.50.0"},"reference-count":53,"publisher":"Society for Neuroscience","issue":"32","license":[{"start":{"date-parts":[[2008,2,8]],"date-time":"2008-02-08T00:00:00Z","timestamp":1202428800000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2007,8,8]]},"abstract":"<jats:p>Calcineurin is a serine\/threonine phosphatase that contributes to the effects of nicotine on calcium signaling in cultured cortical neurons; however, the role of calcineurin in behavioral responses to nicotine<jats:italic>in vivo<\/jats:italic>has not been examined. We therefore determined whether calcineurin blockade could alter nicotine-mediated locomotor sensitization in Sprague Dawley rats using systemic or brain region-specific administration of the calcineurin inhibitors cyclosporine or FK506. Systemic cyclosporine administration decreased calcineurin activity in the brain, attenuated nicotine-mediated locomotor sensitization, and blocked the effects of nicotine on DARPP32 (dopamine- and cAMP-regulated phosphoprotein-32) activation in the striatum. Direct infusion of calcineurin inhibitors cyclosporine or FK506 into the ventral tegmental area (VTA) also attenuated nicotine-mediated locomotor sensitization, whereas infusion of rapamycin, which binds to FK-binding protein but does not inhibit calcineurin, did not affect sensitization. Together, the data suggest that activation of calcineurin, particularly in the VTA, is a novel signaling event important for nicotine-mediated behavior and intracellular signaling.<\/jats:p>","DOI":"10.1523\/jneurosci.2601-07.2007","type":"journal-article","created":{"date-parts":[[2007,8,8]],"date-time":"2007-08-08T17:23:23Z","timestamp":1186593803000},"page":"8571-8580","source":"Crossref","is-referenced-by-count":21,"title":["Role of Calcineurin in Nicotine-Mediated Locomotor Sensitization"],"prefix":"10.1523","volume":"27","author":[{"given":"Nii A.","family":"Addy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio F.","family":"Fornasiero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya R.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane R.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina R.","family":"Picciotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"393","published-online":{"date-parts":[[2007,8,8]]},"reference":[{"key":"2023041303265169000_27.32.8571.1","doi-asserted-by":"publisher","DOI":"10.1038\/326704a0"},{"key":"2023041303265169000_27.32.8571.2","first-page":"327","article-title":"Calcium channel antagonists suppress nicotine-induced place preference and locomotor sensitization in rodents","volume":"55","author":"Biala","year":"2003","journal-title":"Pol J Pharmacol"},{"key":"2023041303265169000_27.32.8571.3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01640.x"},{"key":"2023041303265169000_27.32.8571.4","first-page":"1145","article-title":"Tobacco use among adults\u2014United States 2005","volume":"55","year":"2006","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2023041303265169000_27.32.8571.5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.13.7750"},{"key":"2023041303265169000_27.32.8571.6","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90401-4"},{"key":"2023041303265169000_27.32.8571.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01930-5"},{"key":"2023041303265169000_27.32.8571.8","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1152\/jn.00843.2001","article-title":"Stimulation of 5-HT(2) receptors in prefrontal pyramidal neurons inhibits Ca.(v)1.2 L type Ca(2+) currents via a PLCbeta\/IP3\/calcineurin signaling cascade","volume":"87","author":"Day","year":"2002","journal-title":"J Neurophysiol"},{"key":"2023041303265169000_27.32.8571.9","first-page":"71","article-title":"Pharmacokinetics of cyclosporine in toxicological studies","volume":"28","author":"Donatsch","year":"1986","journal-title":"Transplant Proc"},{"key":"2023041303265169000_27.32.8571.10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2001.02009.x"},{"key":"2023041303265169000_27.32.8571.11","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0022-3565(24)39093-7","article-title":"Systemic nicotine stimulates dopamine release in nucleus accumbens: re-evaluation of the role of N-methyl-D-aspartate receptors in the ventral tegmental area","volume":"294","author":"Fu","year":"2000","journal-title":"J Pharamcol Exp Ther"},{"key":"2023041303265169000_27.32.8571.12","doi-asserted-by":"publisher","DOI":"10.1126\/science.8430330"},{"key":"2023041303265169000_27.32.8571.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80798-9"},{"key":"2023041303265169000_27.32.8571.14","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2396(200010)38:1<1::AID-SYN1>3.0.CO;2-A"},{"key":"2023041303265169000_27.32.8571.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.09.002"},{"key":"2023041303265169000_27.32.8571.16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02574.x"},{"key":"2023041303265169000_27.32.8571.17","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050145"},{"key":"2023041303265169000_27.32.8571.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2004.11.002"},{"key":"2023041303265169000_27.32.8571.19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4278-04.2005"},{"key":"2023041303265169000_27.32.8571.20","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300654"},{"key":"2023041303265169000_27.32.8571.21","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.96.5.1374"},{"key":"2023041303265169000_27.32.8571.22","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(86)90629-1"},{"key":"2023041303265169000_27.32.8571.23","doi-asserted-by":"publisher","DOI":"10.1007\/s002130100852"},{"key":"2023041303265169000_27.32.8571.24","doi-asserted-by":"crossref","first-page":"7944","DOI":"10.1523\/JNEUROSCI.21-20-07944.2001","article-title":"Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+-dependent glutamate release in isolated nerve terminals","volume":"21","author":"Jovanovic","year":"2001","journal-title":"J Neurosci"},{"key":"2023041303265169000_27.32.8571.25","doi-asserted-by":"publisher","DOI":"10.1038\/73888"},{"key":"2023041303265169000_27.32.8571.26","doi-asserted-by":"crossref","first-page":"8080","DOI":"10.1016\/S0021-9258(17)39694-1","article-title":"Mammalian brain phosphoproteins as substrates for calcineurin","volume":"259","author":"King","year":"1984","journal-title":"J Biol Chem"},{"key":"2023041303265169000_27.32.8571.27","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(92)90370-5"},{"key":"2023041303265169000_27.32.8571.28","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1523\/JNEUROSCI.21-05-01452.2001","article-title":"Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei","volume":"21","author":"Klink","year":"2001","journal-title":"J Neurosci"},{"key":"2023041303265169000_27.32.8571.29","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001197"},{"key":"2023041303265169000_27.32.8571.30","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1298"},{"key":"2023041303265169000_27.32.8571.31","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S1016-8478(23)13057-3","article-title":"Calcineurin in animal behavior","volume":"17","author":"Lee","year":"2004","journal-title":"Mol Cells"},{"key":"2023041303265169000_27.32.8571.32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.23.9574"},{"key":"2023041303265169000_27.32.8571.33","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90124-H"},{"key":"2023041303265169000_27.32.8571.34","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81150-2"},{"key":"2023041303265169000_27.32.8571.35","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0656-0"},{"key":"2023041303265169000_27.32.8571.36","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00625-6"},{"key":"2023041303265169000_27.32.8571.37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejphar.2005.03.017","article-title":"Desensitization of nicotine acetylcholine receptors: modulation by kinase activation and phosphatase inhibition","volume":"514","author":"Marszalec","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"2023041303265169000_27.32.8571.38","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.57.030195.002513"},{"key":"2023041303265169000_27.32.8571.39","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00602.x"},{"key":"2023041303265169000_27.32.8571.40","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0006-8993(96)00432-5","article-title":"Nicotine injections into the ventral tegmental area increase locomotion and Fos-like immunoreactivity in the nucleus accumbens of the rat","volume":"730","author":"Panagis","year":"1996","journal-title":"Brain Res"},{"key":"2023041303265169000_27.32.8571.41","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(98)00074-X"},{"key":"2023041303265169000_27.32.8571.42","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00021-7"},{"key":"2023041303265169000_27.32.8571.43","doi-asserted-by":"crossref","first-page":"10093","DOI":"10.1523\/JNEUROSCI.23-31-10093.2003","article-title":"Neuroprotection by nicotine in mouse primary cortical cultures involves activation of calcineurin and L-type calcium channel inactivation","volume":"23","author":"Stevens","year":"2003","journal-title":"J Neurosci"},{"key":"2023041303265169000_27.32.8571.44","doi-asserted-by":"publisher","DOI":"10.1007\/BF01345242"},{"key":"2023041303265169000_27.32.8571.45","doi-asserted-by":"publisher","DOI":"10.1007\/BF00966669"},{"key":"2023041303265169000_27.32.8571.46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408305102"},{"key":"2023041303265169000_27.32.8571.47","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301033"},{"key":"2023041303265169000_27.32.8571.48","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1523\/JNEUROSCI.23-03-00826.2003","article-title":"Interaction of calcineurin and type-A GABA receptor \u03b32 subunits produces long-term depression at CA1 inhibitory synapses","volume":"23","author":"Wang","year":"2003","journal-title":"J Neurosci"},{"key":"2023041303265169000_27.32.8571.49","doi-asserted-by":"publisher","DOI":"10.1038\/35081514"},{"key":"2023041303265169000_27.32.8571.50","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(97)01046-8"},{"key":"2023041303265169000_27.32.8571.51","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1080\/15216540600791555","article-title":"Effects of cyclosporin A, FK506 and rapamycin on calcineurin phosphatase activity in mouse brain","volume":"58","author":"Yu","year":"2006","journal-title":"IUBMB Life"},{"key":"2023041303265169000_27.32.8571.52","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300832"},{"key":"2023041303265169000_27.32.8571.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.05.026"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.2601-07.2007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T05:55:45Z","timestamp":1737352545000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.2601-07.2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,8]]},"references-count":53,"journal-issue":{"issue":"32","published-online":{"date-parts":[[2007,8,8]]},"published-print":{"date-parts":[[2007,8,8]]}},"alternative-id":["10.1523\/JNEUROSCI.2601-07.2007"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.2601-07.2007","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,8]]}}}