{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:05:54Z","timestamp":1791947154873,"version":"4.3.4"},"reference-count":35,"publisher":"Society for Neuroscience","issue":"1","license":[{"start":{"date-parts":[[2006,7,4]],"date-time":"2006-07-04T00:00:00Z","timestamp":1151971200000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2006,1,4]]},"abstract":"<jats:p>Loss-of-function mutations or abnormal expression of the X-linked gene encoding methyl CpG binding protein 2 (MeCP2) cause a spectrum of postnatal neurodevelopmental disorders including Rett syndrome (RTT), nonsyndromic mental retardation, learning disability, and autism. Mice expressing a truncated allele of<jats:italic>Mecp2<\/jats:italic>(<jats:italic>Mecp2<\/jats:italic><jats:sup>308<\/jats:sup>) reproduce the motor and social behavior abnormalities of RTT; however, it is not known whether learning deficits are present in these animals. We investigated learning and memory, neuronal morphology, and synaptic function in<jats:italic>Mecp2<\/jats:italic><jats:sup>308<\/jats:sup>mice. Hippocampus-dependent spatial memory, contextual fear memory, and social memory were significantly impaired in<jats:italic>Mecp2<\/jats:italic><jats:sup>308<\/jats:sup>mutant males (<jats:italic>Mecp2<\/jats:italic><jats:sup>308\/Y<\/jats:sup>). The morphology of dendritic arborizations, the biochemical composition of synaptosomes and postsynaptic densities, and<jats:italic>brain-derived neurotrophic factor<\/jats:italic>expression were not altered in these mice. However, reduced postsynaptic density cross-sectional length was identified in asymmetric synapses of area CA1 of the hippocampus. In the hippocampus of symptomatic<jats:italic>Mecp2<\/jats:italic><jats:sup>308\/Y<\/jats:sup>mice, Schaffer-collateral synapses exhibited enhanced basal synaptic transmission and decreased paired-pulse facilitation, suggesting that neurotransmitter release was enhanced. Schaffer-collateral long-term potentiation (LTP) was impaired. LTP was also reduced in the motor and sensory regions of the neocortex. Finally, very early symptomatic<jats:italic>Mecp2<\/jats:italic><jats:sup>308\/Y<\/jats:sup>mice had increased basal synaptic transmission and deficits in the induction of long-term depression. These data demonstrate a requirement for MeCP2 in learning and memory and suggest that functional and ultrastructural synaptic dysfunction is an early event in the pathogenesis of RTT.<\/jats:p>","DOI":"10.1523\/jneurosci.2623-05.2006","type":"journal-article","created":{"date-parts":[[2006,1,4]],"date-time":"2006-01-04T17:08:02Z","timestamp":1136394482000},"page":"319-327","source":"Crossref","is-referenced-by-count":462,"title":["Learning and Memory and Synaptic Plasticity Are Impaired in a Mouse Model of Rett Syndrome"],"prefix":"10.1523","volume":"26","author":[{"given":"Paolo","family":"Moretti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Levenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fortunato","family":"Battaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Teague","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Antalffy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawna","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ottavio","family":"Arancio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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