{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:37:40Z","timestamp":1785559060482,"version":"3.56.0"},"reference-count":27,"publisher":"Society for Neuroscience","issue":"42","license":[{"start":{"date-parts":[[2009,4,15]],"date-time":"2009-04-15T00:00:00Z","timestamp":1239753600000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2008,10,15]]},"abstract":"<jats:p><jats:italic>Stargazer<\/jats:italic>mice are characterized by ataxia and seizures, which resemble the human disorder absence epilepsy. Stargazin, the protein mutated in<jats:italic>stargazer<\/jats:italic>mice, promotes the expression and function of neuronal AMPA receptors (AMPARs). However, it is unclear how decreased expression of excitatory AMPARs generates<jats:italic>stargazer<\/jats:italic>seizures, given that seizures often result from increased neuronal excitability. Additionally, although<jats:italic>stargazer<\/jats:italic>ataxia has been attributed to loss of AMPARs from cerebellar granule cells, other cerebellar neurons have not been examined. To examine the role of AMPAR dysfunction in these behavioral phenotypes, electrophysiological recordings were used to probe AMPAR regulation in relevant brain regions. We found that both cerebellar Purkinje cells and inhibitory thalamic reticular nucleus neurons have strongly reduced synaptic AMPAR function in<jats:italic>stargazer<\/jats:italic>mice. Together, our data suggest that impaired AMPAR regulation in multiple neuron populations may contribute to the behavioral phenotypes of absence seizures and ataxia seen in<jats:italic>stargazer<\/jats:italic>mice and imply that an understanding of human genetic disorders will require knowledge of both the genes that are mutated as well as their precise cellular expression pattern.<\/jats:p>","DOI":"10.1523\/jneurosci.2732-08.2008","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T16:28:33Z","timestamp":1224088113000},"page":"10599-10603","source":"Crossref","is-referenced-by-count":80,"title":["Loss of Inhibitory Neuron AMPA Receptors Contributes to Ataxia and Epilepsy in<i>Stargazer<\/i>Mice"],"prefix":"10.1523","volume":"28","author":[{"given":"Karen","family":"Menuz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A.","family":"Nicoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2008,10,15]]},"reference":[{"key":"2023041303343554000_28.42.10599.1","doi-asserted-by":"crossref","first-page":"6095","DOI":"10.1523\/JNEUROSCI.21-16-06095.2001","article-title":"Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells","volume":"21","author":"Barclay","year":"2001","journal-title":"J Neurosci"},{"key":"2023041303343554000_28.42.10599.2","doi-asserted-by":"publisher","DOI":"10.1038\/88254"},{"key":"2023041303343554000_28.42.10599.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81877-2"},{"key":"2023041303343554000_28.42.10599.4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.21.12132"},{"key":"2023041303343554000_28.42.10599.5","doi-asserted-by":"publisher","DOI":"10.1038\/35050030"},{"key":"2023041303343554000_28.42.10599.6","doi-asserted-by":"publisher","DOI":"10.1038\/81566"},{"key":"2023041303343554000_28.42.10599.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81381-1"},{"key":"2023041303343554000_28.42.10599.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2005.08.009"},{"key":"2023041303343554000_28.42.10599.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2006.01.004"},{"key":"2023041303343554000_28.42.10599.10","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5561-06.2007"},{"key":"2023041303343554000_28.42.10599.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01306-5"},{"key":"2023041303343554000_28.42.10599.12","doi-asserted-by":"publisher","DOI":"10.1038\/nature05453"},{"key":"2023041303343554000_28.42.10599.13","doi-asserted-by":"publisher","DOI":"10.1038\/1228"},{"key":"2023041303343554000_28.42.10599.14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.63.1.815"},{"key":"2023041303343554000_28.42.10599.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.09.086"},{"key":"2023041303343554000_28.42.10599.16","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1319-08.2008"},{"key":"2023041303343554000_28.42.10599.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2008.04.004"},{"key":"2023041303343554000_28.42.10599.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.08.022"},{"key":"2023041303343554000_28.42.10599.19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5270-06.2007"},{"key":"2023041303343554000_28.42.10599.20","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200702054"},{"key":"2023041303343554000_28.42.10599.21","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1523\/JNEUROSCI.13-11-04622.1993","article-title":"Developmental analysis of hippocampal mossy fiber outgrowth in a mutant mouse with inherited spike-wave seizures","volume":"13","author":"Qiao","year":"1993","journal-title":"J Neurosci"},{"key":"2023041303343554000_28.42.10599.22","doi-asserted-by":"publisher","DOI":"10.1038\/nn1551"},{"key":"2023041303343554000_28.42.10599.23","doi-asserted-by":"publisher","DOI":"10.1038\/ng0198-25"},{"key":"2023041303343554000_28.42.10599.24","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1152\/jn.1998.80.2.520","article-title":"Postsynaptic current mediated by metabotropic glutamate receptors in cerebellar Purkinje cells","volume":"80","author":"Tempia","year":"1998","journal-title":"J Neurophysiol"},{"key":"2023041303343554000_28.42.10599.25","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200212116"},{"key":"2023041303343554000_28.42.10599.26","doi-asserted-by":"publisher","DOI":"10.1038\/1252"},{"key":"2023041303343554000_28.42.10599.27","doi-asserted-by":"crossref","first-page":"6362","DOI":"10.1523\/JNEUROSCI.22-15-06362.2002","article-title":"Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons","volume":"22","author":"Zhang","year":"2002","journal-title":"J Neurosci"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.2732-08.2008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T18:50:51Z","timestamp":1681411851000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.2732-08.2008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,15]]},"references-count":27,"journal-issue":{"issue":"42","published-online":{"date-parts":[[2008,10,15]]},"published-print":{"date-parts":[[2008,10,15]]}},"alternative-id":["10.1523\/JNEUROSCI.2732-08.2008"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.2732-08.2008","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,15]]}}}