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We examined how aging and A\u03b2 deposition affect neural function during memory encoding of visual scenes using functional magnetic resonance imaging (fMRI) in humans. Thirty-six cognitively normal older people underwent fMRI scanning, and positron emission tomography with [<jats:sup>11<\/jats:sup>C] Pittsburgh compound B to measure fibrillar brain A\u03b2; 15 young subjects were studied with fMRI. Older adults without A\u03b2 deposition showed reduced regional brain activation (compared with young subjects) with decreased task-independent functional connectivity between parahippocampal gyrus and prefrontal cortex. In this network, task-related connectivity was increased compared with young subjects, and the degree of connectivity was related to memory performance. In contrast, older individuals with A\u03b2 deposition showed no such increased task-related network connectivity, but did display increased regional activity unassociated with performance. These findings suggest that network connectivity plays a significant role in compensating for reduced regional activity during successful memory encoding in aging without A\u03b2 deposition, while in those with A\u03b2 this network compensation fails and is accompanied by inefficient regional hyperactivation.<\/jats:p>","DOI":"10.1523\/jneurosci.2775-13.2013","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T18:14:31Z","timestamp":1384971271000},"page":"18425-18437","source":"Crossref","is-referenced-by-count":59,"title":["Frontotemporal Network Connectivity during Memory Encoding Is Increased with Aging and Disrupted by Beta-Amyloid"],"prefix":"10.1523","volume":"33","author":[{"given":"Hwamee","family":"Oh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Jagust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2013,11,20]]},"reference":[{"key":"2023041304080119000_33.47.18425.1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0030017"},{"key":"2023041304080119000_33.47.18425.2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812697106"},{"key":"2023041304080119000_33.47.18425.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.10.038"},{"key":"2023041304080119000_33.47.18425.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.11.012"},{"key":"2023041304080119000_33.47.18425.5","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000219668.47116.e6"},{"key":"2023041304080119000_33.47.18425.6","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5845-11.2012"},{"key":"2023041304080119000_33.47.18425.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008173430701"},{"key":"2023041304080119000_33.47.18425.8","unstructured":"Brett M Anton J-L Valabregue R Poline J-B (2002) Region of interest analysis using an SPM toolbox. 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