{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:16:22Z","timestamp":1791533782894,"version":"4.3.4"},"reference-count":41,"publisher":"Society for Neuroscience","issue":"35","license":[{"start":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T00:00:00Z","timestamp":1172620800000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2006,8,30]]},"abstract":"<jats:p>\n                    Various environmental and genetic factors influence the onset and progression of Alzheimer\u2019s disease (AD). Dysregulation of the hypothalamic\u2013pituitary\u2013adrenal (HPA) axis, which controls circulating levels of glucocorticoid hormones, occurs early in AD, resulting in increased cortisol levels. Disturbances of the HPA axis have been associated with memory impairments and may contribute to the cognitive decline that occurs in AD, although it is unknown whether such effects involve modulation of the amyloid \u03b2-peptide (A\u03b2) and tau. Using\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    experiments, we report that stress-level glucocorticoid administration increases A\u03b2 formation by increasing steady-state levels of amyloid precursor protein (APP) and \u03b2-APP cleaving enzyme. Additionally, glucocorticoids augment tau accumulation, indicating that this hormone also accelerates the development of neurofibrillary tangles. These findings suggest that high levels of glucocorticoids, found in AD, are not merely a consequence of the disease process but rather play a central role in the development and progression of AD.\n                  <\/jats:p>","DOI":"10.1523\/jneurosci.2797-06.2006","type":"journal-article","created":{"date-parts":[[2006,8,30]],"date-time":"2006-08-30T20:39:46Z","timestamp":1156970386000},"page":"9047-9056","source":"Crossref","is-referenced-by-count":564,"title":["Glucocorticoids Increase Amyloid-\u03b2 and Tau Pathology in a Mouse Model of Alzheimer\u2019s Disease"],"prefix":"10.1523","volume":"26","author":[{"given":"Kim N.","family":"Green","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Billings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benno","family":"Roozendaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"McGaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M.","family":"LaFerla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2006,8,30]]},"reference":[{"key":"2023041303201533000_26.35.9047.1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2000.00475.x"},{"key":"2023041303201533000_26.35.9047.2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.3.588"},{"key":"2023041303201533000_26.35.9047.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.01.040"},{"key":"2023041303201533000_26.35.9047.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(97)00062-6"},{"key":"2023041303201533000_26.35.9047.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00790-9"},{"key":"2023041303201533000_26.35.9047.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2005.08.001"},{"key":"2023041303201533000_26.35.9047.7","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1176\/ajp.143.3.300","article-title":"Cortisol and Alzheimer\u2019s disease. 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