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Short-term oral administration of TAK-070 decreased the brain levels of soluble A\u03b2, increased that of neurotrophic sAPP\u03b1 by \u223c20%, and normalized the behavioral impairments in cognitive tests in Tg2576 mice, an APP transgenic mouse model of AD. Six-month chronic treatment decreased cerebral A\u03b2 deposition by \u223c60%, preserving the pharmacological efficacy on soluble A\u03b2 and sAPP\u03b1 levels. These results support the feasibility of BACE1 inhibition with a noncompetitive inhibitor as disease-modifying as well as symptomatic therapy for AD.<\/jats:p>","DOI":"10.1523\/jneurosci.2884-10.2010","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T18:12:40Z","timestamp":1282155160000},"page":"11157-11166","source":"Crossref","is-referenced-by-count":109,"title":["A Noncompetitive BACE1 Inhibitor TAK-070 Ameliorates A\u03b2 Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's 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