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We used CP55940, a potent agonist of brain cannabinoid receptors known to disrupt coordinated activity in hippocampus, to investigate the roles of network oscillations during hippocampal and medial prefrontal cortical (mPFC) interactions in rats. During quiet wakefulness and rest, CP55940 dose-dependently reduced 0.1\u201330 Hz local field potential power in CA1 of the hippocampus while concurrently decreasing 30\u2013100 Hz power in mPFC; these contrasting population-level effects were paralleled by differential effects on underlying single-unit activity in the two structures. During decision-making phases of a spatial working memory task, CP5540-induced deficits in hippocampal theta and prefrontal gamma oscillations were observed alongside disrupted theta-frequency coherence between the two structures. These changes in coordinated limbic\u2013cortical network activities correlated with (1) reduced accuracy of task performance, (2) impaired phase-locking of prefrontal single-unit spiking to the local gamma and hippocampal theta rhythms, and (3) impaired task-dependent activity in a subset of mPFC units. In addition to highlighting the importance of CA1\u2013mPFC network oscillations for cognition, these results implicate disrupted theta-frequency coordination of CA1\u2013mPFC activity in the cognitive deficits caused by exogenous activation of brain cannabinoid receptors.<\/jats:p>","DOI":"10.1523\/jneurosci.2970-11.2011","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T17:05:00Z","timestamp":1319648700000},"page":"15560-15568","source":"Crossref","is-referenced-by-count":59,"title":["Dysfunctional Prefrontal Cortical Network Activity and Interactions following Cannabinoid Receptor Activation"],"prefix":"10.1523","volume":"31","author":[{"given":"Michal T.","family":"Kucewicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Tricklebank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafal","family":"Bogacz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2011,10,26]]},"reference":[{"key":"2023041303531510000_31.43.15560.1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp223"},{"key":"2023041303531510000_31.43.15560.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.05.013"},{"key":"2023041303531510000_31.43.15560.3","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0442-05.2005"},{"key":"2023041303531510000_31.43.15560.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.06.020"},{"key":"2023041303531510000_31.43.15560.5","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(82)90071-5"},{"key":"2023041303531510000_31.43.15560.6","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.7.772"},{"key":"2023041303531510000_31.43.15560.7","doi-asserted-by":"crossref","first-page":"605-","DOI":"10.1126\/science.1167768","article-title":"Neural mechanisms of a genome-wide supported psychosis variant","volume":"324","author":"Esslinger","year":"2009","journal-title":"Science"},{"key":"2023041303531510000_31.43.15560.8","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2979"},{"key":"2023041303531510000_31.43.15560.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2006.02.008"},{"key":"2023041303531510000_31.43.15560.10","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1523\/JNEUROSCI.17-05-01880.1997","article-title":"Selective roles for hippocampal, prefrontal cortical, and ventral striatal circuits in radial-arm maze tasks with or without a delay","volume":"17","author":"Floresco","year":"1997","journal-title":"J Neurosci"},{"key":"2023041303531510000_31.43.15560.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2005.08.011"},{"key":"2023041303531510000_31.43.15560.12","doi-asserted-by":"crossref","unstructured":"Gilmour G Dix S Fellini L Gastambide F Plath N Steckler T Talpos J Tricklebank M (2011) NMDA receptors, cognition and schizophrenia-testing the validity of the NMDA receptor hypofunction hypothesis. 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