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Here we show that in mice, chronic 5-HT transporter (5-HTT) blockade during adulthood but not during development impairs basal ganglia-dependent behaviors in a dose-dependent and reversible fashion. Furthermore, chronic 5-HTT blockade reduces striatal dopamine (DA) content and metabolism. A causal relationship between reduced DA signaling and impaired basal ganglia-dependent behavior is indicated by the reversal of behavioral deficits through<jats:sc>l<\/jats:sc>-DOPA administration. Our data suggest that augmentation of DA signaling would reduce side effects and increase efficacies of SSRI-based therapy.<\/jats:p>","DOI":"10.1523\/jneurosci.2989-11.2011","type":"journal-article","created":{"date-parts":[[2011,11,2]],"date-time":"2011-11-02T17:03:41Z","timestamp":1320253421000},"page":"15742-15750","source":"Crossref","is-referenced-by-count":40,"title":["Chronic 5-HT Transporter Blockade Reduces DA Signaling to Elicit Basal Ganglia Dysfunction"],"prefix":"10.1523","volume":"31","author":[{"given":"Emanuela","family":"Morelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahilia 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