{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:11:39Z","timestamp":1791303099620,"version":"4.1.0"},"reference-count":35,"publisher":"Society for Neuroscience","issue":"43","license":[{"start":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T00:00:00Z","timestamp":1303862400000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2010,10,27]]},"abstract":"<jats:p>Alterations in cortical excitability are implicated in the pathophysiology of migraine. However, the relationship between cortical spreading depression (CSD) and headache has not been fully elucidated. We aimed to identify the corticofugal networks that directly influence meningeal nociception in the brainstem trigeminocervical complex (Sp5C) of the rat. Cortical areas projecting to the brainstem were first identified by retrograde tracing from Sp5C areas that receive direct meningeal inputs. Anterograde tracers were then injected into these cortical areas to determine the precise pattern of descending axonal terminal fields in the Sp5C. Descending cortical projections to brainstem areas innervated by the ophthalmic branch of the trigeminal nerve originate contralaterally from insular (Ins) and primary somatosensory (S1) cortices and terminate in laminae I\u2013II and III\u2013V of the Sp5C, respectively. In another set of experiments, electrophysiological recordings were simultaneously performed in Ins, S1 or primary visual cortex (V1), and Sp5C neurons. KCl was microinjected into such cortical areas to test the effects of CSD on meningeal nociception. CSD initiated in Ins and S1 induced facilitation and inhibition of meningeal-evoked responses, respectively. CSD triggered in V1 affects differently Ins and S1 cortices, enhancing or inhibiting meningeal-evoked responses of Sp5C, without affecting cutaneous-evoked nociceptive responses. Our data suggest that \u201ctop-down\u201d influences from lateralized areas within Ins and S1 selectively affect interoceptive (meningeal) over exteroceptive (cutaneous) nociceptive inputs onto Sp5C. Such corticofugal influences could contribute to the development of migraine pain in terms of both topographic localization and pain tuning during an attack.<\/jats:p>","DOI":"10.1523\/jneurosci.3025-10.2010","type":"journal-article","created":{"date-parts":[[2010,10,27]],"date-time":"2010-10-27T14:05:06Z","timestamp":1288188306000},"page":"14420-14429","source":"Crossref","is-referenced-by-count":115,"title":["Changes of Meningeal Excitability Mediated by Corticotrigeminal Networks: A Link for the Endogenous Modulation of Migraine Pain"],"prefix":"10.1523","volume":"30","author":[{"given":"Rodrigo","family":"Noseda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Constandil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Bourgeais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryse","family":"Chalus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Villanueva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2010,10,27]]},"reference":[{"key":"2023041303470153000_30.43.14420.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.02.004"},{"key":"2023041303470153000_30.43.14420.2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0202-136"},{"key":"2023041303470153000_30.43.14420.3","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1293"},{"key":"2023041303470153000_30.43.14420.4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1999.3903181.x"},{"key":"2023041303470153000_30.43.14420.5","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1152\/jn.1998.79.2.964","article-title":"Chemical stimulation of the intracranial dura induces enhanced responses to facial stimulation in brain stem trigeminal neurons","volume":"79","author":"Burstein","year":"1998","journal-title":"J Neurophysiol"},{"key":"2023041303470153000_30.43.14420.6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp338"},{"key":"2023041303470153000_30.43.14420.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01983.x"},{"key":"2023041303470153000_30.43.14420.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01500.x"},{"key":"2023041303470153000_30.43.14420.9","doi-asserted-by":"publisher","DOI":"10.1038\/nrn894"},{"key":"2023041303470153000_30.43.14420.10","doi-asserted-by":"publisher","DOI":"10.1038\/nn1176"},{"key":"2023041303470153000_30.43.14420.11","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990726)410:2<178::AID-CNE2>3.0.CO;2-F"},{"key":"2023041303470153000_30.43.14420.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(98)00017-4"},{"key":"2023041303470153000_30.43.14420.13","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200101)49:1<7::AID-ANA4>3.0.CO;2-K"},{"key":"2023041303470153000_30.43.14420.14","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200101)49:1<4::AID-ANA3>3.0.CO;2-W"},{"key":"2023041303470153000_30.43.14420.15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.071582498"},{"key":"2023041303470153000_30.43.14420.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61626-8"},{"key":"2023041303470153000_30.43.14420.17","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2411"},{"key":"2023041303470153000_30.43.14420.18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1999.019007631.x"},{"key":"2023041303470153000_30.43.14420.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01572.x"},{"key":"2023041303470153000_30.43.14420.20","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1152\/jn.1944.7.6.359","article-title":"Spreading depression of activity in cerebral cortex","volume":"7","author":"Le\u00e3o","year":"1944","journal-title":"J Neurophysiol"},{"key":"2023041303470153000_30.43.14420.21","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00029.2002"},{"key":"2023041303470153000_30.43.14420.22","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1293-06.2006"},{"key":"2023041303470153000_30.43.14420.23","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1212\/WNL.41.2_Part_1.182","article-title":"The visceral organ brain: implications for the pathophysiology of vascular head pain","volume":"41","author":"Moskowitz","year":"1991","journal-title":"Neurology"},{"key":"2023041303470153000_30.43.14420.24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01588.x"},{"key":"2023041303470153000_30.43.14420.25","unstructured":"Paxinos G Watson C (1998) The rat brain in stereotaxic coordinates (Academic, San Diego)."},{"key":"2023041303470153000_30.43.14420.26","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1102"},{"key":"2023041303470153000_30.43.14420.27","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1991.1103129.x"},{"key":"2023041303470153000_30.43.14420.28","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90484-3"},{"key":"2023041303470153000_30.43.14420.29","doi-asserted-by":"publisher","DOI":"10.1017\/S1464793106007081"},{"key":"2023041303470153000_30.43.14420.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.03.010"},{"key":"2023041303470153000_30.43.14420.31","doi-asserted-by":"publisher","DOI":"10.1038\/384560a0"},{"key":"2023041303470153000_30.43.14420.32","unstructured":"Villanueva L Fields H (2004) in The pain system in normal and pathological states: a primer for clinicians, Endogenous central mechanisms of pain modulation, eds Villanueva L Dickenson AH Ollat H (International Association for the Study of Pain, Seattle), pp 223\u2013243."},{"key":"2023041303470153000_30.43.14420.33","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901750202"},{"key":"2023041303470153000_30.43.14420.34","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0511-10.2010"},{"key":"2023041303470153000_30.43.14420.35","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90201-4"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.3025-10.2010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T16:08:08Z","timestamp":1681402088000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.3025-10.2010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,27]]},"references-count":35,"journal-issue":{"issue":"43","published-online":{"date-parts":[[2010,10,27]]},"published-print":{"date-parts":[[2010,10,27]]}},"alternative-id":["10.1523\/JNEUROSCI.3025-10.2010"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.3025-10.2010","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.5825956.5808054","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.5825956.14779067","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.5825956.7832059","asserted-by":"object"}]},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,27]]}}}