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To study the function of these ET cells within the glomerular network, we developed a \u201chemibulb\u201d preparation that maintains IBPs intact enabling the select activation of ET cells associated with specific glomeruli. Using P2-GFP mice, a line in which the P2 glomeruli are labeled with green fluorescent protein, we recorded from P2 mitral cells (MT cells) while selectively stimulating P2 ET cells. Here, we show that ET-cell activity evokes a slow modulatory (SM) potential within MT cells, which is mediated by the glomerular network and consists of both excitatory and inhibitory components. Interestingly, the timing of the SM potential with respect to olfactory nerve (ON) stimulation can produce converse effects on MT-cell output. When ET-cell activity precedes ON stimulation, the MT-cell response is potentiated; however, when ET-cell activity follows ON stimulation, the MT-cell response is inhibited. Thus, intrabulbar projecting ET cells can shape olfactory bulb output through intraglomerular modulation of MT cells.<\/jats:p>","DOI":"10.1523\/jneurosci.3082-08.2008","type":"journal-article","created":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T16:33:55Z","timestamp":1222878835000},"page":"9920-9928","source":"Crossref","is-referenced-by-count":33,"title":["Intrabulbar Projecting External Tufted Cells Mediate a Timing-Based Mechanism That Dynamically Gates Olfactory Bulb 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