{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:10:04Z","timestamp":1790856604289,"version":"4.1.0"},"reference-count":55,"publisher":"Society for Neuroscience","issue":"44","license":[{"start":{"date-parts":[[2006,5,2]],"date-time":"2006-05-02T00:00:00Z","timestamp":1146528000000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2005,11,2]]},"abstract":"<jats:p>The mammalian voltage-dependent KCNQ channels are responsible for distinct types of native potassium currents and are associated with several human diseases. We cloned a novel<jats:italic>Drosophila<\/jats:italic>KCNQ channel (dKCNQ) based on its sequence homology to the mammalian genes. When expressed in Chinese hamster ovary cells, dKCNQ gives rise to a slowly activating and slowly deactivating current that activates in the subthreshold voltage range. Like the M-current produced by mammalian KCNQ channels, dKCNQ current is sensitive to the KCNQ-specific blocker linopirdine and is suppressed by activation of a muscarinic receptor. dKCNQ is also similar to the mammalian channels in that it binds calmodulin (CaM), and CaM binding is necessary to produce functional currents.<jats:italic>In situ<\/jats:italic>hybridization analysis demonstrates that<jats:italic>dKCNQ<\/jats:italic>mRNA is present in brain cortical neurons, the cardia (proventriculus), and the nurse cells and oocytes of the ovary. We generated mutant flies with deletions in the genomic sequence of<jats:italic>dKCNQ<\/jats:italic>. Embryos produced by homozygous deletion females exhibit disorganized nuclei and fail to hatch, suggesting strongly that a maternal contribution of dKCNQ protein and\/or mRNA is essential for early embryonic development.<\/jats:p>","DOI":"10.1523\/jneurosci.3086-05.2005","type":"journal-article","created":{"date-parts":[[2005,11,2]],"date-time":"2005-11-02T21:38:17Z","timestamp":1130967497000},"page":"10147-10156","source":"Crossref","is-referenced-by-count":24,"title":["A<i>Drosophila<\/i>KCNQ Channel Essential for Early Embryonic Development"],"prefix":"10.1523","volume":"25","author":[{"given":"Hua","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Weiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya S.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Shahidullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samae S.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin B.","family":"Levitan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2005,11,2]]},"reference":[{"key":"2023041303152921000_25.44.10147.1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5461.2185"},{"key":"2023041303152921000_25.44.10147.2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90160-F"},{"key":"2023041303152921000_25.44.10147.3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1857984"},{"key":"2023041303152921000_25.44.10147.4","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1523\/JNEUROSCI.18-12-04673.1998","volume":"18","year":"1998","journal-title":"J Neurosci"},{"key":"2023041303152921000_25.44.10147.5","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5349.403"},{"key":"2023041303152921000_25.44.10147.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6107(00)00004-3"},{"key":"2023041303152921000_25.44.10147.7","doi-asserted-by":"publisher","DOI":"10.1038\/283673a0"},{"key":"2023041303152921000_25.44.10147.8","doi-asserted-by":"publisher","DOI":"10.1038\/ng0198-53"},{"key":"2023041303152921000_25.44.10147.9","doi-asserted-by":"publisher","DOI":"10.1038\/16703"},{"key":"2023041303152921000_25.44.10147.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(97)00155-X"},{"key":"2023041303152921000_25.44.10147.11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.21.8415"},{"key":"2023041303152921000_25.44.10147.12","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200208783"},{"key":"2023041303152921000_25.44.10147.13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.31.22109"},{"key":"2023041303152921000_25.44.10147.14","unstructured":"Hille B (2001) Ionic channels of excitable membranes. 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