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Rats with pretraining lesions to the prefrontal cortex (PFC) or specific lesions to the anterior cingulate cortex (ACC) were trained and tested on a novel behavioral procedure measuring aspects of cue and response competition typical of tests of prefrontal function in humans. Rats were trained on two biconditional discrimination tasks, one auditory and one visual, in two discriminably different contexts. At test, they received presentations of audiovisual compounds of these training stimuli in both contexts, in extinction. These compounds were formed in such way that the individual elements had dictated either the same (congruent trials) or different (incongruent trials) responses during training. Sham-operated rats used the contextual cues to disambiguate the conflicting response information provided by incongruent stimulus compounds. ACC lesions impaired the contextual control of instrumental responding during incongruent cues during only the initial period of cue presentation, whereas larger PFC lesions abolished incongruent cue performance completely. Neither biconditional discrimination acquisition, nor test performance during congruent stimulus compounds, were affected by the lesions. These findings are consistent with human and nonhuman primate studies, indicating a role for the PFC in the processes by which cues come to control behavior in the face of conflicting information and the ACC specifically in processes such as detection of response conflict. This procedure provides a good foundation for an improved understanding of the disruption to goal-directed behavior seen with frontal dysfunction in a number of neuropsychological disorders including schizophrenia.<\/jats:p>","DOI":"10.1523\/jneurosci.3243-05.2006","type":"journal-article","created":{"date-parts":[[2006,3,15]],"date-time":"2006-03-15T18:18:10Z","timestamp":1142446690000},"page":"2933-2940","source":"Crossref","is-referenced-by-count":79,"title":["Prefrontal Cortex Lesions Disrupt the Contextual Control of Response Conflict"],"prefix":"10.1523","volume":"26","author":[{"given":"Josephine E.","family":"Haddon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Killcross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2006,3,15]]},"reference":[{"key":"2023041303171911000_26.11.2933.1","doi-asserted-by":"publisher","DOI":"10.1038\/46035"},{"key":"2023041303171911000_26.11.2933.2","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5364.747"},{"key":"2023041303171911000_26.11.2933.3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.4.1944"},{"key":"2023041303171911000_26.11.2933.4","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.99.1.45"},{"key":"2023041303171911000_26.11.2933.5","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.97.3.332"},{"key":"2023041303171911000_26.11.2933.6","doi-asserted-by":"crossref","unstructured":"Cohen JD, Braver TS, O\u2019Reilly RC (1998) A computational approach to prefrontal cortex, cognitive control and schizophrenia: recent developments and current challenges. 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