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Here, we examine the effects of 5-HT\n                    <jats:sub>2<\/jats:sub>\n                    receptors in a rat model of psychiatric vulnerability using electrophysiology, gene expression, and behavior. Following the early stress of chronic maternal separation, we found that serotonin has atypical 5-HT\n                    <jats:sub>2<\/jats:sub>\n                    receptor-mediated excitatory effects in the adult prefrontal cortex that were blocked by the 5-HT\n                    <jats:sub>2A<\/jats:sub>\n                    receptor antagonist MDL 100907. In the absence of a serotonergic agonist, the intrinsic excitability of the prefrontal cortex was not enhanced relative to controls. Yet, in response to stimulation of 5-HT\n                    <jats:sub>2<\/jats:sub>\n                    receptors, adult animals with a history of early stress exhibit heightened prefrontal network activity\n                    <jats:italic>in vitro<\/jats:italic>\n                    , enhanced immediate early gene expression\n                    <jats:italic>in vivo<\/jats:italic>\n                    , and potentiated head shake behavior. These changes arise in the absence of any major alteration of prefrontal 5-HT\n                    <jats:sub>2A\/C<\/jats:sub>\n                    mRNA expression or 5-HT\n                    <jats:sub>2<\/jats:sub>\n                    receptor binding. Our microarray results and quantitative PCR validation provide insight into the molecular changes that accompany such enhanced 5-HT\n                    <jats:sub>2<\/jats:sub>\n                    receptor function in adult animals following early stress. We observed persistent prefrontal transcriptome changes, with significant enrichment of genes involved in cellular developmental processes, regulation of signal transduction, and G-protein signaling. Specific genes regulated by early stress were validated in an independent cohort, and several altered genes were normalized by chronic blockade of 5-HT\n                    <jats:sub>2<\/jats:sub>\n                    receptors in adulthood. Together, our results demonstrate enhanced prefrontal 5-HT\n                    <jats:sub>2<\/jats:sub>\n                    receptor function and persistent alterations in prefrontal gene expression in a rat model of psychiatric vulnerability.\n                  <\/jats:p>","DOI":"10.1523\/jneurosci.3245-10.2010","type":"journal-article","created":{"date-parts":[[2010,9,8]],"date-time":"2010-09-08T12:47:56Z","timestamp":1283950076000},"page":"12138-12150","source":"Crossref","is-referenced-by-count":87,"title":["Enhanced Function of Prefrontal Serotonin 5-HT\n                    <sub>2<\/sub>\n                    Receptors in a Rat Model of Psychiatric Vulnerability"],"prefix":"10.1523","volume":"30","author":[{"given":"Madhurima","family":"Benekareddy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie 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