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Behavioral studies have revealed maladaptive auditory responses in fragile X syndrome patients and<jats:italic>Fmr1<\/jats:italic>KO mice, suggesting that adaptive plasticity may also be impaired in the auditory system. Here we show that, whereas tonotopic frequency representation develops normally in<jats:italic>Fmr1<\/jats:italic>KO mice, developmental plasticity in primary auditory cortex is grossly impaired. This deficit can be rescued by pharmacological blockade of mGluR5 receptors. These results support the mGluR hypothesis of fragile X mental retardation and suggest that deficient developmental plasticity may contribute to maladaptive auditory processing in fragile X syndrome.<\/jats:p>","DOI":"10.1523\/jneurosci.3246-12.2013","type":"journal-article","created":{"date-parts":[[2013,10,2]],"date-time":"2013-10-02T16:30:49Z","timestamp":1380731449000},"page":"15686-15692","source":"Crossref","is-referenced-by-count":70,"title":["Impaired Critical Period Plasticity in Primary Auditory Cortex of Fragile X Model 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