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We previously demonstrated the SNS outflow from brain to BAT using the retrograde SNS-specific transneuronal viral tract tracer, pseudorabies virus (PRV152) and demonstrated the sensory system (SS) inflow from BAT to brain using the anterograde SS-specific transneuronal viral tract tracer, H129 strain of herpes simplex virus-1. Several brain areas were part of both the SNS outflow to, and receive SS inflow from, interscapular BAT (IBAT) in these separate studies suggesting SNS\u2013SS feedback loops. Therefore, we tested whether individual neurons participated in SNS\u2013SS crosstalk by injecting both PRV152 and H129 into IBAT of Siberian hamsters. To define which dorsal root ganglia (DRG) are activated by BAT SNS stimulation, indicated by c-Fos immunoreactivity (IR), we prelabeled IBAT DRG innervating neurons by injecting the retrograde tracer Fast Blue (FB) followed 1 week later by intra-BAT injections of the specific \u03b2<jats:sub>3<\/jats:sub>-adrenoceptor agonist CL316,243 in one pad and the vehicle in the contralateral pad. There were PRV152+H129 dually infected neurons across the neuroaxis with highest densities in the raphe pallidus nucleus, nucleus of the solitary tract, periaqueductal gray, hypothalamic paraventricular nucleus, and medial preoptic area, sites strongly implicated in the control of BAT thermogenesis. CL316,243 significantly increased IBAT temperature, afferent nerve activity, and c-Fos-IR in C2\u2013C4 DRG neurons ipsilateral to the CL316,243 injections versus the contralateral side. The neuroanatomical reality of the SNS\u2013SS feedback loops suggests coordinated and\/or multiple redundant control of BAT thermogenesis.<\/jats:p>","DOI":"10.1523\/jneurosci.3306-14.2015","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T17:29:49Z","timestamp":1423070989000},"page":"2181-2190","source":"Crossref","is-referenced-by-count":110,"title":["Brown Adipose Tissue Has Sympathetic-Sensory Feedback Circuits"],"prefix":"10.1523","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8068-4577","authenticated-orcid":false,"given":"Vitaly","family":"Ryu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9594-8632","authenticated-orcid":false,"given":"John 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