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Here we report markedly decreased APP expression in dopaminergic neurons of human PD nigra and that<jats:italic>APP<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>mice develop iron-dependent nigral cell loss. Conversely, APP-overexpressing mice are protected in the MPTP PD model. NO suppresses APP translation in mouse MPTP models, explaining how elevated NO causes iron-dependent neurodegeneration in PD.<\/jats:p>","DOI":"10.1523\/jneurosci.3439-14.2015","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T06:43:23Z","timestamp":1424933003000},"page":"3591-3597","source":"Crossref","is-referenced-by-count":132,"title":["Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of \u03b2-Amyloid Precursor 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