{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:20:22Z","timestamp":1791343222224,"version":"4.3.1"},"reference-count":14,"publisher":"Society for Neuroscience","issue":"43","license":[{"start":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T00:00:00Z","timestamp":1429660800000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2014,10,22]]},"abstract":"<jats:p>Magnetoencephalography has long held the promise of providing a noninvasive tool for localizing epileptic seizures in humans because of its high spatial resolution compared with the scalp EEG. Yet, this promise has been elusive, not because of a lack of sensitivity or spatial resolution but because the large size and immobility of present cryogenic (superconducting) technology prevent long-term telemetry required to capture these very infrequent epileptiform events. To circumvent this limitation, we used Micro-Electro-Mechanical Systems technology to construct a noncryogenic (room temperature) microfabricated atomic magnetometer (\u201cmagnetrode\u201d) based on laser spectroscopy of rubidium vapor and similar in size and flexibility to scalp EEG electrodes. We tested the magnetrode by measuring the magnetic signature of epileptiform discharges in a rat model of epilepsy. We were able to measure neuronal currents of single epileptic discharges and more subtle spontaneous brain activity with a high signal-to-noise ratio approaching that of present superconducting sensors. These measurements are a promising step toward the goal of high-resolution noninvasive telemetry of epileptic events in humans with seizure disorders.<\/jats:p>","DOI":"10.1523\/jneurosci.3495-14.2014","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T12:57:56Z","timestamp":1413982676000},"page":"14324-14327","source":"Crossref","is-referenced-by-count":60,"title":["Magnetoencephalography of Epilepsy with a Microfabricated Atomic Magnetrode"],"prefix":"10.1523","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5932-194X","authenticated-orcid":false,"given":"Orang","family":"Alem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex M.","family":"Benison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Barth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kitching","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja","family":"Knappe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2014,10,22]]},"reference":[{"key":"2023041304134201000_34.43.14324.1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6813968"},{"key":"2023041304134201000_34.43.14324.2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6436979"},{"key":"2023041304134201000_34.43.14324.3","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91040-1"},{"key":"2023041304134201000_34.43.14324.4","doi-asserted-by":"publisher","DOI":"10.1038\/nphys566"},{"key":"2023041304134201000_34.43.14324.5","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(83)90005-6"},{"key":"2023041304134201000_34.43.14324.6","unstructured":"Engel J (2013) Seizures and epilepsy (Oxford UP, New York)."},{"key":"2023041304134201000_34.43.14324.7","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197204000-00004"},{"key":"2023041304134201000_34.43.14324.8","first-page":"311","article-title":"An ultra-low-power physics package for a chip-scale atomic clock","volume":"1","author":"Mescher","year":"2005","journal-title":"IEEE Solid-State Sensors Actuators"},{"key":"2023041304134201000_34.43.14324.9","doi-asserted-by":"publisher","DOI":"10.1063\/1.4770361"},{"key":"2023041304134201000_34.43.14324.10","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-4533(99)00088-0"},{"key":"2023041304134201000_34.43.14324.11","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.3.000981"},{"key":"2023041304134201000_34.43.14324.12","doi-asserted-by":"crossref","unstructured":"Schwindt PDD Lindseth B Knappe S Shah V Kitching J Liew LA (2007) Chip-scale atomic magnetometer with improved sensitivity by use of the Mx technique. Applied Phys Lett 90:081102\u2013081103.","DOI":"10.1063\/1.2709532"},{"key":"2023041304134201000_34.43.14324.13","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.110.160802"},{"key":"2023041304134201000_34.43.14324.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01271-4"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.3495-14.2014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T18:14:23Z","timestamp":1681409663000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.3495-14.2014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,22]]},"references-count":14,"journal-issue":{"issue":"43","published-online":{"date-parts":[[2014,10,22]]},"published-print":{"date-parts":[[2014,10,22]]}},"alternative-id":["10.1523\/JNEUROSCI.3495-14.2014"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.3495-14.2014","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.723872107.793502562","asserted-by":"object"}]},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,22]]}}}