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To further establish the phenomenon of surround inhibition and to determine whether short intracortical inhibition (SICI) reflecting inhibition from the local interneurons in primary motor cortex (M1), might play a role in its genesis, single- and paired-pulse transcranial magnetic stimulation (TMS), and Hoffmann reflex testing were applied to evaluate the excitability of the relaxed abductor pollicis brevis muscle (APB) at various intervals during a movement of the index finger in 16 patients with FHD and 20 controls. Whereas controls showed inhibition of APB motor-evoked potential (MEP) size during movement initiation and facilitation of APB MEP size during the maintenance phase, FHD patients did not modulate APB MEP size. In contrast, SICI remained constant in controls, but FHD patients showed reduced SICI during movement initiation. The<jats:italic>H<\/jats:italic><jats:sub>max<\/jats:sub>\/<jats:italic>M<\/jats:italic><jats:sub>max<\/jats:sub>ratio in control subjects increased during movement initiation. The results provide additional evidence for the presence of surround inhibition in M1, where it occurs only during movement initiation, indicating that different mechanisms underlie movement initiation and maintenance. Thus, surround inhibition is sculpted both in time and space and may be an important neural mechanism during movement initiation to counteract increased spinal excitability. SICI may contribute to its generation, because in patients with FHD, the lack of depression of APB MEP size is accompanied by a reduction in SICI.<\/jats:p>","DOI":"10.1523\/jneurosci.3564-08.2008","type":"journal-article","created":{"date-parts":[[2008,10,8]],"date-time":"2008-10-08T16:33:03Z","timestamp":1223483583000},"page":"10363-10369","source":"Crossref","is-referenced-by-count":175,"title":["Short Intracortical and Surround Inhibition Are Selectively Reduced during Movement Initiation in Focal Hand Dystonia"],"prefix":"10.1523","volume":"28","author":[{"given":"Sandra","family":"Beck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Pirio","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ejaz A.","family":"Shamim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyet","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hallett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2008,10,8]]},"reference":[{"key":"2023041303342852000_28.41.10363.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(02)36031-X"},{"key":"2023041303342852000_28.41.10363.2","doi-asserted-by":"publisher","DOI":"10.1038\/228037a0"},{"key":"2023041303342852000_28.41.10363.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-003-1684-1"},{"key":"2023041303342852000_28.41.10363.4","doi-asserted-by":"crossref","unstructured":"Chen R Hallett M (1998) Focal dystonia and repetitive motion disorders. 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