{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:40:56Z","timestamp":1774867256288,"version":"3.50.1"},"reference-count":27,"publisher":"Society for Neuroscience","issue":"41","license":[{"start":{"date-parts":[[2007,4,11]],"date-time":"2007-04-11T00:00:00Z","timestamp":1176249600000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2006,10,11]]},"abstract":"<jats:p>Various studies suggest that proteolytic activity may be involved in a number of neurodegenerative disorders, including stroke and seizure. In this report, we examined the role of tryptic serine proteases, plasminogen activators (PAs), in the evolution of a neurodegenerative disease. Transgenic mice overexpressing an axonally secreted inhibitor of serine proteases (neuroserpin) were crossed with mice characterized by a \u201cdying-back\u201d motor neuron disease [progressive motor neuronopathy (<jats:italic>pmn\/pmn<\/jats:italic>)]. Compared with<jats:italic>pmn\/pmn<\/jats:italic>mice that showed an increase in PA activity, double mutant mice had decreased PA activity in sciatic nerves and spinal cord; their lifespan was increased by 50%, their motor behavior was stabilized, and histological analysis revealed increased numbers of myelinated axons and rescue of motoneuron number and size. This is the first report showing that a class of serine proteases (PAs) may be involved in the pathogenesis of a motor neuron disease and more specifically in axonal degeneration. Inhibiting serine proteases could offer a new strategy for delaying these disorders.<\/jats:p>","DOI":"10.1523\/jneurosci.3582-06.2006","type":"journal-article","created":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T17:30:03Z","timestamp":1160587803000},"page":"10614-10619","source":"Crossref","is-referenced-by-count":15,"title":["An Inhibitor of Serine Proteases, Neuroserpin, Acts as a Neuroprotective Agent in a Mouse Model of Neurodegenerative Disease"],"prefix":"10.1523","volume":"26","author":[{"given":"Yannick","family":"Simonin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Charron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Sonderegger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Dominique","family":"Vassalli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann C.","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"393","published-online":{"date-parts":[[2006,10,11]]},"reference":[{"key":"2023041303212223000_26.41.10614.1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00690805"},{"key":"2023041303212223000_26.41.10614.2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90958-C"},{"key":"2023041303212223000_26.41.10614.3","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200208001"},{"key":"2023041303212223000_26.41.10614.4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.3.1554"},{"key":"2023041303212223000_26.41.10614.5","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2001.1028"},{"key":"2023041303212223000_26.41.10614.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(98)00241-0"},{"key":"2023041303212223000_26.41.10614.7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0002-9440(10)62996-3","article-title":"A role for the plasminogen activator system in inflammation and neurodegeneration in the central nervous system during experimental allergic encephalomyelitis","volume":"167","author":"East","year":"2005","journal-title":"Am J Pathol"},{"key":"2023041303212223000_26.41.10614.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(03)00206-9"},{"key":"2023041303212223000_26.41.10614.9","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(20000215)29:4<347::AID-GLIA5>3.0.CO;2-8"},{"key":"2023041303212223000_26.41.10614.10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2741\/1778","article-title":"Neuroserpin","volume":"11","author":"Galliciotti","year":"2006","journal-title":"Front Biosci"},{"key":"2023041303212223000_26.41.10614.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00183-5"},{"key":"2023041303212223000_26.41.10614.12","doi-asserted-by":"crossref","first-page":"10781","DOI":"10.1523\/JNEUROSCI.22-24-10781.2002","article-title":"Involvement of tissue plasminogen activator in onset and effector phases of experimental allergic encephalomyelitis","volume":"22","author":"Lu","year":"2002","journal-title":"J Neurosci"},{"key":"2023041303212223000_26.41.10614.13","doi-asserted-by":"publisher","DOI":"10.1038\/ng1016"},{"key":"2023041303212223000_26.41.10614.14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600650"},{"key":"2023041303212223000_26.41.10614.15","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-12-0838"},{"key":"2023041303212223000_26.41.10614.16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.4.2312"},{"key":"2023041303212223000_26.41.10614.17","doi-asserted-by":"publisher","DOI":"10.1038\/ng1012"},{"key":"2023041303212223000_26.41.10614.18","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0413-04.2004"},{"key":"2023041303212223000_26.41.10614.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1995.tb01122.x"},{"key":"2023041303212223000_26.41.10614.20","doi-asserted-by":"crossref","first-page":"7727","DOI":"10.1523\/JNEUROSCI.15-11-07727.1995","article-title":"Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease","volume":"15","author":"Sagot","year":"1995","journal-title":"J Neurosci"},{"key":"2023041303212223000_26.41.10614.21","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1523\/JNEUROSCI.16-07-02335.1996","article-title":"GDNF slows loss of motoneurons but not axonal degeneration or premature death of pmn\/pmn mice","volume":"16","author":"Sagot","year":"1996","journal-title":"J Neurosci"},{"key":"2023041303212223000_26.41.10614.22","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199105000-00002"},{"key":"2023041303212223000_26.41.10614.23","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.1523\/JNEUROSCI.21-12-04348.2001","article-title":"Mice lacking tPA, uPA, or plasminogen genes showed delayed functional recovery after sciatic nerve crush","volume":"21","author":"Siconolfi","year":"2001","journal-title":"J Neurosci"},{"key":"2023041303212223000_26.41.10614.24","doi-asserted-by":"publisher","DOI":"10.1084\/jem.159.6.1653"},{"key":"2023041303212223000_26.41.10614.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.10.052"},{"key":"2023041303212223000_26.41.10614.26","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1182\/blood.V96.2.569.014k35_569_576","article-title":"Neuroserpin reduces cerebral infarct volume and protects neurons from ischemia-induced apoptosis","volume":"96","author":"Yepes","year":"2000","journal-title":"Blood"},{"key":"2023041303212223000_26.41.10614.27","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/01.jnen.0000195942.25163.f5","article-title":"Exogenous tissue plasminogen activator enhances peripheral nerve regeneration and functional recovery after injury in mice","volume":"65","author":"Zou","year":"2006","journal-title":"J Neuropathol Exp Neurol"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.3582-06.2006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T17:38:37Z","timestamp":1681407517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.3582-06.2006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,11]]},"references-count":27,"journal-issue":{"issue":"41","published-online":{"date-parts":[[2006,10,11]]},"published-print":{"date-parts":[[2006,10,11]]}},"alternative-id":["10.1523\/JNEUROSCI.3582-06.2006"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.3582-06.2006","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,11]]}}}