{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:41:59Z","timestamp":1790919719524,"version":"4.1.0"},"reference-count":61,"publisher":"Society for Neuroscience","issue":"52","license":[{"start":{"date-parts":[[2008,6,26]],"date-time":"2008-06-26T00:00:00Z","timestamp":1214438400000},"content-version":"vor","delay-in-days":183,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2007,12,26]]},"abstract":"<jats:p>Environmental and genetic factors, notably ApoE4, contribute to the etiology of late-onset Alzheimer's disease (LOAD). Reduced mRNA and protein for an apolipoprotein E (ApoE) receptor family member, SorLA (LR11) has been found in LOAD but not early-onset AD, suggesting that LR11 loss is not secondary to pathology. LR11 is a neuronal sorting protein that reduces amyloid precursor protein (APP) trafficking to secretases that generate \u03b2-amyloid (A\u03b2). Genetic polymorphisms that reduce LR11 expression are associated with increased AD risk. However these polymorphisms account for only a fraction of cases with LR11 deficits, suggesting involvement of environmental factors. Because lipoprotein receptors are typically lipid-regulated, we postulated that LR11 is regulated by docosahexaenoic acid (DHA), an essential \u03c9-3 fatty acid related to reduced AD risk and reduced A\u03b2 accumulation. In this study, we report that DHA significantly increases LR11 in multiple systems, including primary rat neurons, aged non-Tg mice and an aged DHA-depleted APPsw AD mouse model. DHA also increased LR11 in a human neuronal line.<jats:italic>In vivo<\/jats:italic>elevation of LR11 was also observed with dietary fish oil in young rats with insulin resistance, a model for type II diabetes, another AD risk factor. These data argue that DHA induction of LR11 does not require DHA-depleting diets and is not age dependent. Because reduced LR11 is known to increase A\u03b2 production and may be a significant genetic cause of LOAD, our results indicate that DHA increases in SorLA\/LR11 levels may play an important role in preventing LOAD.<\/jats:p>","DOI":"10.1523\/jneurosci.3593-07.2007","type":"journal-article","created":{"date-parts":[[2007,12,26]],"date-time":"2007-12-26T18:29:31Z","timestamp":1198693771000},"page":"14299-14307","source":"Crossref","is-referenced-by-count":85,"title":["Omega-3 Fatty Acid Docosahexaenoic Acid Increases SorLA\/LR11, a Sorting Protein with Reduced Expression in Sporadic Alzheimer's Disease (AD): Relevance to AD Prevention"],"prefix":"10.1523","volume":"27","author":[{"given":"Qiu-Lan","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Teter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver J.","family":"Ubeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Morihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilsher","family":"Dhoot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Nyby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Tuck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally A.","family":"Frautschy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg M.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2007,12,26]]},"reference":[{"key":"2023041303292055000_27.52.14299.1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502903102"},{"key":"2023041303292055000_27.52.14299.2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503689102"},{"key":"2023041303292055000_27.52.14299.3","doi-asserted-by":"publisher","DOI":"10.1038\/ng1197-263"},{"key":"2023041303292055000_27.52.14299.4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7370.932"},{"key":"2023041303292055000_27.52.14299.5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601660200"},{"key":"2023041303292055000_27.52.14299.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.08.013"},{"key":"2023041303292055000_27.52.14299.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04253.x"},{"key":"2023041303292055000_27.52.14299.8","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-1-8"},{"key":"2023041303292055000_27.52.14299.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2006.08.009"},{"key":"2023041303292055000_27.52.14299.10","doi-asserted-by":"publisher","DOI":"10.1051\/rnd:2004033"},{"key":"2023041303292055000_27.52.14299.11","doi-asserted-by":"publisher","DOI":"10.1097\/01.jnen.0000228205.19915.20"},{"key":"2023041303292055000_27.52.14299.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(00)00170-6"},{"key":"2023041303292055000_27.52.14299.13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03541.x"},{"key":"2023041303292055000_27.52.14299.14","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.10.1402"},{"key":"2023041303292055000_27.52.14299.15","doi-asserted-by":"publisher","DOI":"10.1038\/349704a0"},{"key":"2023041303292055000_27.52.14299.16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3233\/JAD-2002-4308","article-title":"The significance of environmental factors in the etiology of Alzheimer's disease","volume":"4","author":"Grant","year":"2002","journal-title":"J Alzheimers Dis"},{"key":"2023041303292055000_27.52.14299.17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0055-07.2007"},{"key":"2023041303292055000_27.52.14299.18","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20051376"},{"key":"2023041303292055000_27.52.14299.19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411296200"},{"key":"2023041303292055000_27.52.14299.20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.49.31379"},{"key":"2023041303292055000_27.52.14299.21","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)03299-9"},{"key":"2023041303292055000_27.52.14299.22","doi-asserted-by":"crossref","first-page":"1494S","DOI":"10.1093\/ajcn\/83.6.1494S","article-title":"Potential role of dietary n-3 fatty acids in the prevention of dementia and macular degeneration","volume":"83","author":"Johnson","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"2023041303292055000_27.52.14299.23","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1212\/01.WNL.0000103860.75218.A5","article-title":"Dietary intake of fatty acids and fish in relation to cognitive performance at middle age","volume":"62","author":"Kalmijn","year":"2004","journal-title":"Neurology"},{"key":"2023041303292055000_27.52.14299.24","doi-asserted-by":"publisher","DOI":"10.1021\/bi035197x"},{"key":"2023041303292055000_27.52.14299.25","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0005-2760(98)00015-0","article-title":"Distinctive inhibitory activity of docosahexaenoic acid against sphingosine-induced apoptosis","volume":"1391","author":"Kishida","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"2023041303292055000_27.52.14299.26","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.4.501"},{"key":"2023041303292055000_27.52.14299.27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb48496.x"},{"key":"2023041303292055000_27.52.14299.28","doi-asserted-by":"crossref","first-page":"8370","DOI":"10.1523\/JNEUROSCI.21-21-08370.2001","article-title":"The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse","volume":"21","author":"Lim","year":"2001","journal-title":"J Neurosci"},{"key":"2023041303292055000_27.52.14299.29","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4225-04.2005"},{"key":"2023041303292055000_27.52.14299.30","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25420"},{"key":"2023041303292055000_27.52.14299.31","unstructured":"Maclean CH Issa AM Newberry SJ Mojica WA Morton SC Garland RH Hilton LG Traina SB Shekelle PG (2005) Effects of omega-3 fatty acids on cognitive function with aging, dementia, and neurological diseases. Evid Rep Technol Assess (Summ) 1\u20133."},{"key":"2023041303292055000_27.52.14299.32","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90219-4"},{"key":"2023041303292055000_27.52.14299.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2003.10.010"},{"key":"2023041303292055000_27.52.14299.34","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.2.194"},{"key":"2023041303292055000_27.52.14299.35","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.7.940"},{"key":"2023041303292055000_27.52.14299.36","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01542-5"},{"key":"2023041303292055000_27.52.14299.37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402531101"},{"key":"2023041303292055000_27.52.14299.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2004.08.030"},{"key":"2023041303292055000_27.52.14299.39","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4946-05.2006"},{"key":"2023041303292055000_27.52.14299.40","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.106.137091"},{"key":"2023041303292055000_27.52.14299.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.04.013"},{"key":"2023041303292055000_27.52.14299.42","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.9.1937"},{"key":"2023041303292055000_27.52.14299.43","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10999"},{"key":"2023041303292055000_27.52.14299.44","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1096\/fasebj.12.15.1777","article-title":"Increased F2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo","volume":"12","author":"Pratic\u00f2","year":"1998","journal-title":"FASEB J"},{"key":"2023041303292055000_27.52.14299.45","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.1523\/JNEUROSCI.21-12-04183.2001","article-title":"Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis","volume":"21","author":"Pratico","year":"2001","journal-title":"J Neurosci"},{"key":"2023041303292055000_27.52.14299.46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0337683100"},{"key":"2023041303292055000_27.52.14299.47","doi-asserted-by":"publisher","DOI":"10.1038\/376775a0"},{"key":"2023041303292055000_27.52.14299.48","doi-asserted-by":"publisher","DOI":"10.1038\/ng1943"},{"key":"2023041303292055000_27.52.14299.49","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.8.1467"},{"key":"2023041303292055000_27.52.14299.50","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.8.1200"},{"key":"2023041303292055000_27.52.14299.51","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200312034"},{"key":"2023041303292055000_27.52.14299.52","doi-asserted-by":"publisher","DOI":"10.1038\/375754a0"},{"key":"2023041303292055000_27.52.14299.53","doi-asserted-by":"publisher","DOI":"10.1007\/BF02536067"},{"key":"2023041303292055000_27.52.14299.54","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3882-05.2006"},{"key":"2023041303292055000_27.52.14299.55","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02202-8"},{"key":"2023041303292055000_27.52.14299.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2006.11.010"},{"key":"2023041303292055000_27.52.14299.57","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200312190-00033"},{"key":"2023041303292055000_27.52.14299.58","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.40.24761"},{"key":"2023041303292055000_27.52.14299.59","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(00)00013-7"},{"key":"2023041303292055000_27.52.14299.60","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2860-04.2004"},{"key":"2023041303292055000_27.52.14299.61","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)00830-4"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.3593-07.2007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T18:28:00Z","timestamp":1681410480000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.3593-07.2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,26]]},"references-count":61,"journal-issue":{"issue":"52","published-online":{"date-parts":[[2007,12,26]]},"published-print":{"date-parts":[[2007,12,26]]}},"alternative-id":["10.1523\/JNEUROSCI.3593-07.2007"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.3593-07.2007","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,26]]}}}