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Here we show that reducing the leak current through the activation of group I metabotropic glutamate receptors (mGluRs) with either<jats:italic>trans<\/jats:italic>-ACPD [(+\/\u2212)-1-aminocyclopentane-<jats:italic>trans<\/jats:italic>-1,3-dicarboxylic acid] (50\u2013100 \u03bc<jats:sc>m<\/jats:sc>) or DHPG [(<jats:italic>S<\/jats:italic>)-3,5-dihydroxyphenylglycine] (100 \u03bc<jats:sc>m<\/jats:sc>) instates an intrinsic slow oscillation in NRT neurons<jats:italic>in vitro<\/jats:italic>that is qualitatively equivalent to that observed<jats:italic>in vivo<\/jats:italic>. A slow oscillation could also be evoked by synaptically activating mGluRs on NRT neurons via the tetanic stimulation of corticothalamic fibers. Through a combination of experiments and computational modeling we show that the up state of the slow oscillation is predominantly generated by the \u201cwindow\u201d component of the T-type Ca<jats:sup>2+<\/jats:sup>current, with an additional supportive role for a Ca<jats:sup>2+<\/jats:sup>-activated nonselective cation current. The slow oscillation is also fundamentally reliant on an<jats:italic>I<\/jats:italic><jats:sub>h<\/jats:sub>current and is extensively shaped by both Ca<jats:sup>2+<\/jats:sup>- and Na<jats:sup>+<\/jats:sup>-activated K<jats:sup>+<\/jats:sup>currents. In combination with previous work in thalamocortical neurons, this study suggests that the thalamus plays an important and active role in shaping the slow (&lt;1 Hz) rhythm during deep sleep.<\/jats:p>","DOI":"10.1523\/jneurosci.3607-05.2006","type":"journal-article","created":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T20:19:10Z","timestamp":1141244350000},"page":"2474-2486","source":"Crossref","is-referenced-by-count":111,"title":["Neuronal Basis of the Slow (&lt;1 Hz) Oscillation in Neurons of the Nucleus Reticularis Thalami<i>In Vitro<\/i>"],"prefix":"10.1523","volume":"26","author":[{"given":"Kate L.","family":"Blethyn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart W.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor 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