{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:50:30Z","timestamp":1789908630078,"version":"4.0.1"},"reference-count":19,"publisher":"Society for Neuroscience","issue":"15","license":[{"start":{"date-parts":[[2006,10,12]],"date-time":"2006-10-12T00:00:00Z","timestamp":1160611200000},"content-version":"vor","delay-in-days":183,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2006,4,12]]},"abstract":"<jats:p>The evolutionarily conserved Semaphorin family proteins are well known axon guidance ligands that mediate both attractive and repulsive responses in invertebrates and vertebrates. In this study, we show that the<jats:italic>Drosophila<\/jats:italic>Semaphorin-1a (Sema1a), a transmembrane Semaphorin, is required cell autonomously in adult photoreceptor (R-cell) axons for the establishment of an appropriate topographic termination pattern in the optic lobe. Loss of<jats:italic>sema1a<\/jats:italic>disrupts the association of neighboring R-cell growth cones leading to defects in local termination pattern, whereas overexpression of<jats:italic>sema1a<\/jats:italic>induces the hyper-fasciculation of R-cell axons. The function of Sema1a in R-cell axon guidance absolutely requires its cytoplasmic domain. We propose that Sema1a functions as a receptor in regulating R-cell axon guidance in the<jats:italic>Drosophila<\/jats:italic>visual system.<\/jats:p>","DOI":"10.1523\/jneurosci.3845-05.2006","type":"journal-article","created":{"date-parts":[[2006,4,12]],"date-time":"2006-04-12T16:52:49Z","timestamp":1144860769000},"page":"3999-4003","source":"Crossref","is-referenced-by-count":51,"title":["Semaphorin-1a Functions as a Guidance Receptor in the<i>Drosophila<\/i>Visual System"],"prefix":"10.1523","volume":"26","author":[{"given":"Patrick","family":"Cafferty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2006,4,12]]},"reference":[{"key":"2023041303174549000_26.15.3999.1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01406"},{"key":"2023041303174549000_26.15.3999.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00122-7"},{"key":"2023041303174549000_26.15.3999.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00876-0"},{"key":"2023041303174549000_26.15.3999.4","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1997.0644"},{"key":"2023041303174549000_26.15.3999.5","doi-asserted-by":"publisher","DOI":"10.1038\/nn976"},{"key":"2023041303174549000_26.15.3999.6","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006316200"},{"key":"2023041303174549000_26.15.3999.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80701-1"},{"key":"2023041303174549000_26.15.3999.8","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90045-0"},{"key":"2023041303174549000_26.15.3999.9","unstructured":"Meinertzhagen IA, Hanson TE (1993) The development of the optic lobe. In: The development of Drosophila melanogaster (Bate M, Martinez-Arias A, eds) pp. 1363\u20131491. 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