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In this study, we identified various parallelisms between progressive MS and the dysmyelinating mouse model<jats:italic>Shiverer<\/jats:italic>and then genetically deleted a major neuron-specific mitochondrial anchoring protein Syntaphilin (SNPH) from the mouse. Prevailing evidence suggests that deletion of SNPH is harmful in demyelination. Surprisingly, SNPH deletion produces striking benefits in the<jats:italic>Shiverer<\/jats:italic>by prolonging survival, reducing cerebellar damage, suppressing oxidative stress, and improving mitochondrial health. In contrast, SNPH deletion does not benefit clinical symptoms in experimental autoimmune encephalomyelitis (EAE), a model for early-phase MS. We propose that deleting mitochondrial anchoring is a novel, specific treatment for progressive MS.<\/jats:p>","DOI":"10.1523\/jneurosci.3859-14.2015","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T16:52:02Z","timestamp":1427907122000},"page":"5293-5306","source":"Crossref","is-referenced-by-count":33,"title":["Deletion of Mitochondrial Anchoring Protects Dysmyelinating Shiverer: Implications for Progressive MS"],"prefix":"10.1523","volume":"35","author":[{"given":"Dinesh 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