{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:46:38Z","timestamp":1791207998882,"version":"4.1.0"},"reference-count":63,"publisher":"Society for Neuroscience","issue":"11","license":[{"start":{"date-parts":[[2007,9,14]],"date-time":"2007-09-14T00:00:00Z","timestamp":1189728000000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2007,3,14]]},"abstract":"<jats:p>\n                    The orexigenic peptide ghrelin stimulates both food intake and growth hormone release and is synthesized in the stomach and in hypothalamic areas involved in feeding control. The suprachiasmatic nuclei of the hypothalamus (SCN) control most circadian rhythms, although there is evidence that some oscillators, such as food-entrainable oscillators, can drive activity rhythms even after SCN ablation. Ghrelin levels exhibit a circadian rhythm and closely follow feeding schedules, making this peptide a putative candidate for food-related entraining signals. We examined the response of the SCN to ghrelin treatments\n                    <jats:italic>in vitro<\/jats:italic>\n                    , by means of electrophysiological and bioluminescence recordings, and\n                    <jats:italic>in vivo<\/jats:italic>\n                    , by assessing effects on the phase of locomotor activity rhythms. Ghrelin applied at circadian time 6\n                    <jats:italic>in vitro<\/jats:italic>\n                    to cultured SCN slices induced an \u223c3 h phase advance. In addition, ghrelin phase advanced the rhythm of PER2::LUC (Period2::Luciferase) expression in cultured SCN explants from\n                    <jats:italic>\n                      mPer2\n                      <jats:sup>Luc<\/jats:sup>\n                    <\/jats:italic>\n                    transgenic mice.\n                    <jats:italic>In vivo<\/jats:italic>\n                    , intraperitoneal administration of ghrelin or a synthetic analog, growth hormone-releasing protein-6 (GHRP-6), to\n                    <jats:italic>ad libitum<\/jats:italic>\n                    fed animals failed to alter circadian phase. When injected after 30 h of food deprivation, GHRP-6 induced a phase advance compared with saline-injected animals. These results indicate that ghrelin may play a role in the circadian system by exerting a direct action on the SCN and that the system as a whole may become sensitive to ghrelin and other feeding-related neuropeptides under conditions of food restriction.\n                  <\/jats:p>","DOI":"10.1523\/jneurosci.3913-06.2007","type":"journal-article","created":{"date-parts":[[2007,3,14]],"date-time":"2007-03-14T12:11:09Z","timestamp":1173874269000},"page":"2890-2895","source":"Crossref","is-referenced-by-count":123,"title":["Ghrelin Effects on the Circadian System of Mice"],"prefix":"10.1523","volume":"27","author":[{"given":"Paola C.","family":"Yannielli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penny C.","family":"Molyneux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego A.","family":"Golombek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2007,3,14]]},"reference":[{"key":"2023041303240642000_27.11.2890.1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(89)90146-7"},{"key":"2023041303240642000_27.11.2890.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.01.003"},{"key":"2023041303240642000_27.11.2890.3","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.034827"},{"key":"2023041303240642000_27.11.2890.4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00294.2004"},{"key":"2023041303240642000_27.11.2890.5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00247.2004"},{"key":"2023041303240642000_27.11.2890.6","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12715-4"},{"key":"2023041303240642000_27.11.2890.7","doi-asserted-by":"publisher","DOI":"10.1177\/074873049701200108"},{"key":"2023041303240642000_27.11.2890.8","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1596"},{"key":"2023041303240642000_27.11.2890.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00063-1"},{"key":"2023041303240642000_27.11.2890.10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00756.2004"},{"key":"2023041303240642000_27.11.2890.11","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S0896-6273(03)00083-7","article-title":"Filling the interstices: ghrelin neurons plug several holes in regulation of energy balance","volume":"37","author":"Dallman","year":"2003","journal-title":"Neuron"},{"key":"2023041303240642000_27.11.2890.12","doi-asserted-by":"publisher","DOI":"10.1101\/gad.183500"},{"key":"2023041303240642000_27.11.2890.13","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.35954"},{"key":"2023041303240642000_27.11.2890.14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00073.2006"},{"key":"2023041303240642000_27.11.2890.15","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-183X.2003.00005.x"},{"key":"2023041303240642000_27.11.2890.16","doi-asserted-by":"publisher","DOI":"10.1038\/nn1656"},{"key":"2023041303240642000_27.11.2890.17","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1159\/000126883","article-title":"Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man","volume":"61","author":"Frieboes","year":"1995","journal-title":"Neuroendocrinology"},{"key":"2023041303240642000_27.11.2890.18","doi-asserted-by":"publisher","DOI":"10.1038\/nn1651"},{"key":"2023041303240642000_27.11.2890.19","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(99)00231-0"},{"key":"2023041303240642000_27.11.2890.20","doi-asserted-by":"publisher","DOI":"10.1210\/en.142.10.4163"},{"key":"2023041303240642000_27.11.2890.21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002784200"},{"key":"2023041303240642000_27.11.2890.22","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.4039"},{"key":"2023041303240642000_27.11.2890.23","doi-asserted-by":"publisher","DOI":"10.1210\/er.20.1.68"},{"key":"2023041303240642000_27.11.2890.24","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(02)00305-1"},{"key":"2023041303240642000_27.11.2890.25","doi-asserted-by":"publisher","DOI":"10.1210\/en.141.12.4797"},{"key":"2023041303240642000_27.11.2890.26","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200307180-00006"},{"key":"2023041303240642000_27.11.2890.27","unstructured":"Klein DC Moore RY Reppert SM (1991) Suprachiasmatic nucleus: the mind's clock (Oxford UP, New York)."},{"key":"2023041303240642000_27.11.2890.28","first-page":"29","article-title":"Circadian rhythm-modulated chemotherapy with high dose 5-fluorouracil against gastrointestinal cancers: evaluation and case report","volume":"62","author":"Kojima","year":"1999","journal-title":"Nagoya J Med Sci"},{"key":"2023041303240642000_27.11.2890.29","doi-asserted-by":"crossref","first-page":"R1527","DOI":"10.1152\/ajpregu.00874.2005","article-title":"Persistence of a behavioral food-anticipatory circadian rhythm following dorsomedial hypothalamic ablation in rats","volume":"290","author":"Landry","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2023041303240642000_27.11.2890.30","doi-asserted-by":"publisher","DOI":"10.1210\/en.143.1.155"},{"key":"2023041303240642000_27.11.2890.31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00493.2005"},{"key":"2023041303240642000_27.11.2890.32","doi-asserted-by":"publisher","DOI":"10.1159\/000054463"},{"key":"2023041303240642000_27.11.2890.33","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00571-4"},{"key":"2023041303240642000_27.11.2890.34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04461.x"},{"key":"2023041303240642000_27.11.2890.35","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4397-04.2005"},{"key":"2023041303240642000_27.11.2890.36","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(93)90145-6"},{"key":"2023041303240642000_27.11.2890.37","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01836-3"},{"key":"2023041303240642000_27.11.2890.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2004.08.038"},{"key":"2023041303240642000_27.11.2890.39","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01919"},{"key":"2023041303240642000_27.11.2890.40","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.10.2552"},{"key":"2023041303240642000_27.11.2890.41","doi-asserted-by":"publisher","DOI":"10.1126\/science.1089459"},{"key":"2023041303240642000_27.11.2890.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2003.07.005"},{"key":"2023041303240642000_27.11.2890.43","doi-asserted-by":"publisher","DOI":"10.1007\/BF00319366"},{"key":"2023041303240642000_27.11.2890.44","first-page":"60","article-title":"Discovery of a putative food anticipatory circadian clock","volume":"31","author":"Silver","year":"2005","journal-title":"Soc Neurosci Abstr"},{"key":"2023041303240642000_27.11.2890.45","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(86)90142-3"},{"key":"2023041303240642000_27.11.2890.46","doi-asserted-by":"publisher","DOI":"10.1177\/074873040201700402"},{"key":"2023041303240642000_27.11.2890.47","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00654-X"},{"key":"2023041303240642000_27.11.2890.48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0305930101"},{"key":"2023041303240642000_27.11.2890.49","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00448.2006"},{"key":"2023041303240642000_27.11.2890.50","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0529"},{"key":"2023041303240642000_27.11.2890.51","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25811"},{"key":"2023041303240642000_27.11.2890.52","doi-asserted-by":"publisher","DOI":"10.1038\/35038090"},{"key":"2023041303240642000_27.11.2890.53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2004.01251.x"},{"key":"2023041303240642000_27.11.2890.54","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0029"},{"key":"2023041303240642000_27.11.2890.55","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)02402-8"},{"key":"2023041303240642000_27.11.2890.56","doi-asserted-by":"crossref","first-page":"E407","DOI":"10.1152\/ajpendo.00184.2002","article-title":"Ghrelin promotes slow-wave sleep in humans","volume":"284","author":"Weikel","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2023041303240642000_27.11.2890.57","doi-asserted-by":"publisher","DOI":"10.1210\/en.141.11.4325"},{"key":"2023041303240642000_27.11.2890.58","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(05)93012-7"},{"key":"2023041303240642000_27.11.2890.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2004.06.001"},{"key":"2023041303240642000_27.11.2890.60","unstructured":"Yannielli PC Harrington ME Golombek DA (2005) The Eighth Latin American Symposium on Chronobiology (October, Cordoba, Argentina), Ghrelin: it's time to eat; effects of a novel feeding-related peptide on the circadian system."},{"key":"2023041303240642000_27.11.2890.61","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-1051"},{"key":"2023041303240642000_27.11.2890.62","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308709101"},{"key":"2023041303240642000_27.11.2890.63","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20823"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.3913-06.2007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T13:53:23Z","timestamp":1681394003000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.3913-06.2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,14]]},"references-count":63,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2007,3,14]]},"published-print":{"date-parts":[[2007,3,14]]}},"alternative-id":["10.1523\/JNEUROSCI.3913-06.2007"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.3913-06.2007","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,14]]}}}