{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:19:59Z","timestamp":1791206399363,"version":"4.1.0"},"reference-count":18,"publisher":"Society for Neuroscience","issue":"28","license":[{"start":{"date-parts":[[2009,1,9]],"date-time":"2009-01-09T00:00:00Z","timestamp":1231459200000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2008,7,9]]},"abstract":"<jats:p>Dopamine receptor signaling exhibits prominent plasticity that is important for the pathogenesis of both addictive and movement disorders. Psychoactive stimulants that activate the dopamine D<jats:sub>1<\/jats:sub>receptor (Drd1a) induce the rapid phosphorylation and activation of extracellular signal-regulated kinase 1\/2 (ERK1\/2) in neurons of the nucleus accumbens and ventral striatum. This response is known to be dependent on the phosphatase inhibitor dopamine- and cAMP-regulated phosphoprotein-32 (DARPP-32) and appears critical for the sensitization of Drd1a responses that contributes to addiction. Loss of dopamine input to the striatum, as in models of Parkinson's disease (PD), also results in a sensitization of responses to dopamine agonists that is manifest by increased activation of ERK1\/2 in the dorsal striatum. Here, we test whether DARPP-32 is required for sensitization of Drd1a responses in a PD model. In the normal dorsal striatum, there is minimal Drd1a-mediated activation of ERK1\/2; however, in the PD model there is robust Drd1a-mediated activation of ERK1\/2. In both wild-type and DARPP-32 knock-out mice, Drd1a robustly induces pERK1\/2 throughout the dopamine-depleted striatum. These findings indicate that Drd1a sensitization relevant for PD occurs by a novel mechanism that does not require DARPP-32.<\/jats:p>","DOI":"10.1523\/jneurosci.3952-07.2008","type":"journal-article","created":{"date-parts":[[2008,7,9]],"date-time":"2008-07-09T16:23:14Z","timestamp":1215620594000},"page":"7113-7120","source":"Crossref","is-referenced-by-count":66,"title":["Differences between Dorsal and Ventral Striatum in Drd1a Dopamine Receptor Coupling of Dopamine- and cAMP-Regulated Phosphoprotein-32 to Activation of Extracellular Signal-Regulated Kinase"],"prefix":"10.1523","volume":"28","author":[{"given":"Charles R.","family":"Gerfen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Paletzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Worley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2008,7,9]]},"reference":[{"key":"2023041303324682000_28.28.7113.1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0836-06.2006"},{"key":"2023041303324682000_28.28.7113.2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.26.12564"},{"key":"2023041303324682000_28.28.7113.3","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5378.838"},{"key":"2023041303324682000_28.28.7113.4","doi-asserted-by":"crossref","first-page":"5042","DOI":"10.1523\/JNEUROSCI.22-12-05042.2002","article-title":"D1 dopamine receptor supersensitivity in the dopamine-depleted striatum results from a switch in the regulation of ERK1\/2\/MAP kinase","volume":"22","author":"Gerfen","year":"2002","journal-title":"J Neurosci"},{"key":"2023041303324682000_28.28.7113.5","doi-asserted-by":"publisher","DOI":"10.1038\/nature02033"},{"key":"2023041303324682000_28.28.7113.6","doi-asserted-by":"publisher","DOI":"10.1126\/science.294.5544.1024"},{"key":"2023041303324682000_28.28.7113.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80798-9"},{"key":"2023041303324682000_28.28.7113.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(02)00307-0"},{"key":"2023041303324682000_28.28.7113.9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.29.051605.113009"},{"key":"2023041303324682000_28.28.7113.10","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5335.58"},{"key":"2023041303324682000_28.28.7113.11","doi-asserted-by":"crossref","unstructured":"Santini E Valjent E Usiello A Carta M Borgkvist A Girault JA Herve D Greengard P Fisone G (2007) Critical involvement of cAMP\/DARPP-32 and extracellular signal-regulated protein kinase signaling in l-DOPA-induced dyskinesia. 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