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Regions in this network undergo cortical thinning and breakdown in structural and functional connectivity over the course of normal aging. In this study, we investigated how changes in cortical thickness (CT), a measure of gray matter integrity, are involved in modifications of sleep SWs during adulthood in humans. Thirty young (mean age = 23.49 years; SD = 2.79) and 33 older (mean age = 60.35 years; SD = 5.71) healthy subjects underwent a nocturnal polysomnography and T1 MRI. We show that, when controlling for age, higher SW density (nb\/min of nonrapid eye movement sleep) was associated with higher CT in cortical regions involved in SW generation surrounding the lateral fissure (insula, superior temporal, parietal, middle frontal), whereas higher SW amplitude was associated with higher CT in middle frontal, medial prefrontal, and medial posterior regions. Mediation analyses demonstrated that thinning in a network of cortical regions involved in SW generation and propagation, but also in cognitive functions, explained the age-related decrease in SW density and amplitude. Altogether, our results suggest that microstructural degradation of specific cortical regions compromise SW generation and propagation in older subjects, critically contributing to age-related changes in SW oscillations.<\/jats:p>","DOI":"10.1523\/jneurosci.3956-14.2015","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T12:45:10Z","timestamp":1432125910000},"page":"7795-7807","source":"Crossref","is-referenced-by-count":158,"title":["Cortical Thinning Explains Changes in Sleep Slow Waves during Adulthood"],"prefix":"10.1523","volume":"35","author":[{"given":"Jonathan","family":"Dub\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolaine","family":"Lafortune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Bedetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maude","family":"Bouchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Fran\u00e7ois","family":"Gagnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Doyon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan C.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Lina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5311-2370","authenticated-orcid":false,"given":"Julie","family":"Carrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2015,5,20]]},"reference":[{"key":"2023041304170941000_35.20.7795.1","unstructured":"Ad-Dab'bagh Y Einarson D Lyttelton O Muehlboeck JS Mok K Ivanov O Vincent RD Lepage C Lerch J Fombonne E Evans AC (2006) Proceedings of the 12th Annual Meeting of the Organization for Human Brain Mapping The CIVET image-processing environment: a fully automated comprehensive pipeline for anatomical neuroimaging research, ed Corbetta M (Neuroimage, Florence, Italy)."},{"key":"2023041304170941000_35.20.7795.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.1993.tb00065.x"},{"key":"2023041304170941000_35.20.7795.3","unstructured":"American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders (APA, Washington, DC)."},{"key":"2023041304170941000_35.20.7795.4","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.1523\/JNEUROSCI.15-06-04658.1995","article-title":"Disconnection of intracortical synaptic linkages disrupts synchronization of a slow oscillation","volume":"15","author":"Amzica","year":"1995","journal-title":"J Neurosci"},{"key":"2023041304170941000_35.20.7795.5","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.56.6.893"},{"key":"2023041304170941000_35.20.7795.6","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1996-11.2011"},{"key":"2023041304170941000_35.20.7795.7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.1996.00009.x"},{"key":"2023041304170941000_35.20.7795.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2011.00916.x"},{"key":"2023041304170941000_35.20.7795.9","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq129"},{"key":"2023041304170941000_35.20.7795.10","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21311"},{"key":"2023041304170941000_35.20.7795.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07543.x"},{"key":"2023041304170941000_35.20.7795.12","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq009"},{"key":"2023041304170941000_35.20.7795.13","first-page":"180","article-title":"Automated 3D nonlinear deformation procedure for determination of gross morphometric variability in human brain","volume":"2359","author":"Collins","year":"1994","journal-title":"Visualization in Biomedical Computing"},{"key":"2023041304170941000_35.20.7795.14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801819105"},{"key":"2023041304170941000_35.20.7795.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.05.041"},{"key":"2023041304170941000_35.20.7795.16","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2007.19.12.2035"},{"key":"2023041304170941000_35.20.7795.17","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn232"},{"key":"2023041304170941000_35.20.7795.18","first-page":"58","article-title":"Symmetric atlasing and model based segmentation: an application to the hippocampus in older adults. 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