{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:27:46Z","timestamp":1792009666154,"version":"4.4.0"},"reference-count":44,"publisher":"Society for Neuroscience","issue":"9","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2006,3,1]]},"abstract":"<jats:p>In the mammalian CNS, oligodendrocyte precursor cells (OPCs) express most neurotransmitter receptors, but their function remains unclear. The current studies suggest a physiological role for glutamate (AMPA and\/or kainate) receptors in OPC migration. AMPA stimulated \u03b1<jats:sub>v<\/jats:sub>integrin-mediated OPC migration by increasing both the rate of cell movement and the frequency of Ca<jats:sup>2+<\/jats:sup>transients. A protein complex containing the myelin proteolipid protein (PLP) and \u03b1<jats:sub>v<\/jats:sub>integrin modulated the AMPA-stimulated migration, and stimulation of OPC AMPA receptors resulted in increased association of the AMPA receptor subunits themselves with the \u03b1<jats:sub>v<\/jats:sub>integrin\/PLP complex. Thus, after AMPA receptor stimulation, an \u03b1<jats:sub>v<\/jats:sub>integrin\/PLP\/neurotransmitter receptor protein complex forms that reduces binding to the extracellular matrix and enhances OPC migration. To assess the extent to which PLP was involved in the AMPA-stimulated migration, OPCs from the myelin-deficient (MD) rat, which has a PLP gene mutation, were analyzed. OPCs from the MD rat had a normal basal migration rate, but AMPA did not stimulate the migration of these cells, suggesting that the PLP\/\u03b1<jats:sub>v<\/jats:sub>integrin complex was important for the AMPA-mediated induction. AMPA-induced modulation of OPC migration was abolished by pertussis toxin, although baseline migration was normal. Thus, G-protein-dependent signaling is crucial for AMPA-stimulated migration of OPCs but not for basal OPC migration. Other signaling pathways involved in this AMPA-stimulated OPC migration were also determined. These studies highlight novel signaling determinants of OPC migration and suggest that glutamate could play a pivotal role in regulating integrin-mediated OPC migration.<\/jats:p>","DOI":"10.1523\/jneurosci.4054-05.2006","type":"journal-article","created":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T20:19:10Z","timestamp":1141244350000},"page":"2458-2466","source":"Crossref","is-referenced-by-count":182,"title":["Glutamate Stimulates Oligodendrocyte Progenitor Migration Mediated via an \u03b1<sub>v<\/sub>Integrin\/Myelin Proteolipid Protein Complex"],"prefix":"10.1523","volume":"26","author":[{"given":"Tatyana I.","family":"Gudz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Komuro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy 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