{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:43:02Z","timestamp":1791639782477,"version":"4.3.4"},"reference-count":80,"publisher":"Society for Neuroscience","issue":"6","license":[{"start":{"date-parts":[[2005,8,9]],"date-time":"2005-08-09T00:00:00Z","timestamp":1123545600000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2005,2,9]]},"abstract":"<jats:p>We wanted to ascertain whether the lateral parabrachial nucleus was involved in mediating the heart-rate response evoked during stimulation of somatic nociceptors. Reversible inactivation of the lateral parabrachial nucleus, using a GABA<jats:sub>A<\/jats:sub>agonist, reduced the reflex tachycardia evoked during noxious (mechanical) stimulation of the forelimb by \u223c50%. The same effect was observed after blockade of neurokinin 1 receptors within the lateral parabrachial nucleus, indicating a possible involvement for substance P as a neurotransmitter. Immunocytochemistry revealed a strong expression of substance P-immunoreactive fibers and boutons in all lateral subnuclei, but they were particularly dense in the lateral crescent subnucleus. Histological verification showed that the most effective injection sites for attenuating the noxious-evoked tachycardia were all placed in or near to the lateral crescent nucleus of the lateral parabrachial complex. Many single units recorded from this region were activated by high-intensity brachial nerve stimulation. The brachial nerve evoked firing responses of some of these neurons was reversibly reduced after local delivery of a neurokinin 1 receptor antagonist. However, only a minority of these neurons followed a paired-pulse stimulation protocol applied to the spinal cord, suggesting a predominance of indirect projections from the spinal cord to the parabrachial nucleus. We conclude that the cardiac component of the response to somatic nociception involves indirect spinal pathways that most likely excite neurons located in the lateral crescent nucleus of the parabrachial complex via activation of neurokinin 1 receptors.<\/jats:p>","DOI":"10.1523\/jneurosci.4075-04.2005","type":"journal-article","created":{"date-parts":[[2005,2,9]],"date-time":"2005-02-09T21:52:47Z","timestamp":1107985967000},"page":"1412-1420","source":"Crossref","is-referenced-by-count":11,"title":["Neurokininergic Mechanism within the Lateral Crescent Nucleus of the Parabrachial Complex Participates in the Heart-Rate Response to Nociception"],"prefix":"10.1523","volume":"25","author":[{"given":"Pedro","family":"Boscan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Dutschmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Herbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian F. R.","family":"Paton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2005,2,9]]},"reference":[{"key":"2023041303105901000_25.6.1412.1","first-page":"R576","volume":"245","year":"1983","journal-title":"Am J Physiol"},{"key":"2023041303105901000_25.6.1412.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00122-0"},{"key":"2023041303105901000_25.6.1412.3","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903150307"},{"key":"2023041303105901000_25.6.1412.4","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90802-W"},{"key":"2023041303105901000_25.6.1412.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(97)00602-3"},{"key":"2023041303105901000_25.6.1412.6","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901900205"},{"key":"2023041303105901000_25.6.1412.7","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960311)366:3<431::AID-CNE5>3.0.CO;2-5"},{"key":"2023041303105901000_25.6.1412.8","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1152\/jn.1990.63.3.473","volume":"63","year":"1990","journal-title":"J Neurophysiol"},{"key":"2023041303105901000_25.6.1412.9","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1152\/jn.1994.71.5.1646","volume":"71","year":"1994","journal-title":"J Neurophysiol"},{"key":"2023041303105901000_25.6.1412.10","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903530403"},{"key":"2023041303105901000_25.6.1412.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)61868-3"},{"key":"2023041303105901000_25.6.1412.12","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1152\/jn.1995.73.2.568","volume":"73","year":"1995","journal-title":"J Neurophysiol"},{"key":"2023041303105901000_25.6.1412.13","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970714)383:4<439::AID-CNE4>3.0.CO;2-3"},{"key":"2023041303105901000_25.6.1412.14","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1152\/jn.2000.83.4.2239","volume":"83","year":"2000","journal-title":"J Neurophysiol"},{"key":"2023041303105901000_25.6.1412.15","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(87)90102-1"},{"key":"2023041303105901000_25.6.1412.16","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)91563-1"},{"key":"2023041303105901000_25.6.1412.17","doi-asserted-by":"crossref","unstructured":"Boscan P, Paton JFR (2001a) Role of the lateral parabrachial nucleus in mediating the cardiorespiratory reflex responses evoked by somatic noxious stimulation of the forelimb in the rat. Paper presented at Proceedings of the IUPS Meeting, Christchurch, New Zealand, September.","DOI":"10.1016\/S1566-0702(00)00255-1"},{"key":"2023041303105901000_25.6.1412.18","doi-asserted-by":"publisher","DOI":"10.1016\/S1566-0702(00)00255-1"},{"key":"2023041303105901000_25.6.1412.19","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00585-1"},{"key":"2023041303105901000_25.6.1412.20","doi-asserted-by":"crossref","first-page":"H1278","DOI":"10.1152\/ajpcell.00589.2001","volume":"282","year":"2002","journal-title":"Am J Physiol"},{"key":"2023041303105901000_25.6.1412.21","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02131.x"},{"key":"2023041303105901000_25.6.1412.22","doi-asserted-by":"publisher","DOI":"10.1113\/eph8702353"},{"key":"2023041303105901000_25.6.1412.23","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902400205"},{"key":"2023041303105901000_25.6.1412.24","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903260207"},{"key":"2023041303105901000_25.6.1412.25","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903610204"},{"key":"2023041303105901000_25.6.1412.26","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903530404"},{"key":"2023041303105901000_25.6.1412.27","unstructured":"Feil K, Herbert H (1996) Neuropeptides in spinal and medullary projections to the rat internal lateral parabrachial nucleus. In: Proceedings of the 24th G\u00f6ttingen Neurobiology Conference (Elsner N, Schnitzler H-U, eds), p 530. Stuttgart, Germany: Thieme."},{"key":"2023041303105901000_25.6.1412.28","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.63.1.35"},{"key":"2023041303105901000_25.6.1412.29","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0165-0173(84)90012-2","volume":"7","year":"1984","journal-title":"Brain Res Rev"},{"key":"2023041303105901000_25.6.1412.30","doi-asserted-by":"publisher","DOI":"10.1113\/eph8702357"},{"key":"2023041303105901000_25.6.1412.31","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90911-6"},{"key":"2023041303105901000_25.6.1412.32","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903540307"},{"key":"2023041303105901000_25.6.1412.33","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902930404"},{"key":"2023041303105901000_25.6.1412.34","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960422)368:1<45::AID-CNE4>3.0.CO;2-K"},{"key":"2023041303105901000_25.6.1412.35","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903080210"},{"key":"2023041303105901000_25.6.1412.36","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90436-6"},{"key":"2023041303105901000_25.6.1412.37","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01913-7"},{"key":"2023041303105901000_25.6.1412.38","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1523\/JNEUROSCI.17-10-03751.1997","volume":"17","year":"1997","journal-title":"J Neurosci"},{"key":"2023041303105901000_25.6.1412.39","doi-asserted-by":"publisher","DOI":"10.1113\/eph8702355"},{"key":"2023041303105901000_25.6.1412.40","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(89)90258-9"},{"key":"2023041303105901000_25.6.1412.41","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903280310"},{"key":"2023041303105901000_25.6.1412.42","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(92)90137-6"},{"key":"2023041303105901000_25.6.1412.43","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20001218)428:3<475::AID-CNE6>3.0.CO;2-9"},{"key":"2023041303105901000_25.6.1412.44","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19981130)401:4<437::AID-CNE2>3.0.CO;2-5"},{"key":"2023041303105901000_25.6.1412.45","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90439-M"},{"key":"2023041303105901000_25.6.1412.46","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90035-3"},{"key":"2023041303105901000_25.6.1412.47","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1113\/jphysiol.1994.sp020193","volume":"477","year":"1994","journal-title":"J Physiol (Lond)"},{"key":"2023041303105901000_25.6.1412.48","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(88)90323-5"},{"key":"2023041303105901000_25.6.1412.49","doi-asserted-by":"publisher","DOI":"10.1002\/syn.1096"},{"key":"2023041303105901000_25.6.1412.50","unstructured":"Light AR, Casale E, Sedivec M (1987) The physiology and anatomy of spinal lamina I and II neurones antidromically activated by stimulation in the parabrachial region of the midbrain and pons. In: Fine afferent nerve fibers and pain (Schmidt RF, Schaible HG, Vahle-Hinz C, eds), pp 348-356. New York: Wiley VCH."},{"key":"2023041303105901000_25.6.1412.51","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901810211"},{"key":"2023041303105901000_25.6.1412.52","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90119-2"},{"key":"2023041303105901000_25.6.1412.53","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1152\/jn.1996.75.5.2099","volume":"75","year":"1996","journal-title":"J Neurophysiol"},{"key":"2023041303105901000_25.6.1412.54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1991.tb00087.x"},{"key":"2023041303105901000_25.6.1412.55","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1113\/jphysiol.1988.sp017086","volume":"399","year":"1988","journal-title":"J Physiol (Lond)"},{"key":"2023041303105901000_25.6.1412.56","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1152\/jn.1986.55.5.1076","volume":"55","year":"1986","journal-title":"J Neurophysiol"},{"key":"2023041303105901000_25.6.1412.57","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(86)90040-0"},{"key":"2023041303105901000_25.6.1412.58","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902260311"},{"key":"2023041303105901000_25.6.1412.59","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902950408"},{"key":"2023041303105901000_25.6.1412.60","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90610-2"},{"key":"2023041303105901000_25.6.1412.61","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(90)90021-5"},{"key":"2023041303105901000_25.6.1412.62","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1203\/00006450-199904010-00011","volume":"45","year":"1999","journal-title":"Pediatr Res"},{"key":"2023041303105901000_25.6.1412.63","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(85)90078-8"},{"key":"2023041303105901000_25.6.1412.64","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(95)00147-6"},{"key":"2023041303105901000_25.6.1412.65","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1113\/jphysiol.1990.sp018235","volume":"428","year":"1990","journal-title":"J Physiol (Lond)"},{"key":"2023041303105901000_25.6.1412.66","unstructured":"Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates, Ed 2. New York: Academic."},{"key":"2023041303105901000_25.6.1412.67","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)91125-3"},{"key":"2023041303105901000_25.6.1412.68","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902930306"},{"key":"2023041303105901000_25.6.1412.69","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198105000-00008"},{"key":"2023041303105901000_25.6.1412.70","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960311)366:3<390::AID-CNE2>3.0.CO;2-#"},{"key":"2023041303105901000_25.6.1412.71","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903530402"},{"key":"2023041303105901000_25.6.1412.72","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)91117-8"},{"key":"2023041303105901000_25.6.1412.73","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.1152\/jn.1996.76.6.3750","volume":"76","year":"1996","journal-title":"J Neurophysiol"},{"key":"2023041303105901000_25.6.1412.74","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903390106"},{"key":"2023041303105901000_25.6.1412.75","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1523\/JNEUROSCI.06-05-01220.1986","volume":"6","year":"1986","journal-title":"J Neurosci"},{"key":"2023041303105901000_25.6.1412.76","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1569-9048(03)00193-9","volume":"139","year":"2003","journal-title":"Respir Physiol Neurobiol"},{"key":"2023041303105901000_25.6.1412.77","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00156-D"},{"key":"2023041303105901000_25.6.1412.78","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1152\/jappl.2000.88.6.2062","volume":"88","year":"2000","journal-title":"J Appl Physiol"},{"key":"2023041303105901000_25.6.1412.79","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)90570-7"},{"key":"2023041303105901000_25.6.1412.80","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00431.x"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.4075-04.2005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T16:34:48Z","timestamp":1681403688000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.4075-04.2005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,9]]},"references-count":80,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2005,2,9]]},"published-print":{"date-parts":[[2005,2,9]]}},"alternative-id":["10.1523\/JNEUROSCI.4075-04.2005"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.4075-04.2005","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2,9]]}}}