{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:18:51Z","timestamp":1791807531043,"version":"4.3.4"},"reference-count":14,"publisher":"Society for Neuroscience","issue":"46","license":[{"start":{"date-parts":[[2010,5,18]],"date-time":"2010-05-18T00:00:00Z","timestamp":1274140800000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2009,11,18]]},"abstract":"<jats:p>Destruction or changes associated with myelin membranes in the CNS play a key role in the pathogenesis of multiple sclerosis and other related neurodegenerative disorders. A long-standing goal has been to detect and quantify myelin content<jats:italic>in vivo<\/jats:italic>. For this reason, we have developed a myelin-imaging technique based on positron emission tomography (PET). PET is a quantitative imaging modality that has been widely used in clinical settings for direct assessment of biological processes at the molecular level. However, lack of myelin-imaging probes has hampered the use of PET for imaging of myelination in the CNS. Here, we report a myelin-imaging agent, termed Case Imaging Compound (CIC) that readily penetrates the blood\u2013brain barrier and preferentially localizes to myelinated regions of the brain. After radiolabeling with positron-emitting carbon-11, [<jats:sup>11<\/jats:sup>C]CIC\u2013PET was conducted in longitudinal studies using a lysolethicin-induced rat model of focal demyelination and subsequent remyelination. Quantitative analysis showed that the retention of [<jats:sup>11<\/jats:sup>C]CIC correlates with the level of demyelination\/remyelination. These studies indicate that, for the first time, [<jats:sup>11<\/jats:sup>C]CIC\u2013PET can be used as an imaging marker of myelination, which has the potential to be translated into clinical studies in multiple sclerosis and other myelin-related diseases for early diagnosis, subtyping, and efficacy evaluation of therapeutic treatments aimed at myelin repair.<\/jats:p>","DOI":"10.1523\/jneurosci.4082-08.2009","type":"journal-article","created":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T00:01:28Z","timestamp":1258588888000},"page":"14663-14669","source":"Crossref","is-referenced-by-count":65,"title":["<i>In Vivo<\/i>Quantification of Myelin Changes in the Vertebrate Nervous 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