{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:23:49Z","timestamp":1792481029256,"version":"4.5.0"},"reference-count":43,"publisher":"Society for Neuroscience","issue":"4","license":[{"start":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T00:00:00Z","timestamp":1311638400000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2011,1,26]]},"abstract":"<jats:p>As stimulus size increases, motion direction of high-contrast patterns becomes increasingly harder to perceive. This counterintuitive behavioral result, termed \u201cspatial suppression,\u201d is hypothesized to reflect center\u2013surround antagonism\u2014a receptive field property ubiquitous in sensory systems. Prior research proposed that spatial suppression of motion signals is a direct correlate of center\u2013surround antagonism within cortical area MT. Here, we investigated whether human MT\/V5 is indeed causally involved in spatial suppression of motion signals. The key assumption is that a disruption of neural mechanisms that play a critical role in spatial suppression could allow these normally suppressed motion signals to reach perceptual awareness. Thus, our hypothesis was that a disruption of MT\/V5 should weaken spatial suppression and, consequently, improve motion perception of large, moving patterns. To disrupt MT\/V5, we used offline 1 Hz transcranial magnetic stimulation (TMS)\u2014a method that temporarily attenuates normal functioning of the targeted cortex. Early visual areas were also targeted as a control site. The results supported our hypotheses and showed that disruption of MT\/V5 improved motion discrimination of large, moving stimuli, presumably by weakening surround suppression strength. This effect was specific to MT\/V5 stimulation and contralaterally presented stimuli. Evidently, the critical neural constraints limiting motion perception of large, high-contrast stimuli involve MT\/V5. Additionally, our findings mimic spatial suppression deficits that are observed in several patient populations and implicate impaired MT\/V5 processes as likely neural correlates for the reported perceptual abnormalities in the elderly, patients with schizophrenia and those with a history of depression.<\/jats:p>","DOI":"10.1523\/jneurosci.4121-10.2011","type":"journal-article","created":{"date-parts":[[2011,1,27]],"date-time":"2011-01-27T18:19:30Z","timestamp":1296152370000},"page":"1279-1283","source":"Crossref","is-referenced-by-count":117,"title":["Improved Motion Perception and Impaired Spatial Suppression following Disruption of Cortical Area 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