{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:44:33Z","timestamp":1773276273119,"version":"3.50.1"},"reference-count":93,"publisher":"Society for Neuroscience","issue":"6","license":[{"start":{"date-parts":[[2007,8,7]],"date-time":"2007-08-07T00:00:00Z","timestamp":1186444800000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2007,2,7]]},"abstract":"<jats:p>Primary progressive aphasia (PPA) is a neurodegenerative dementia syndrome principally characterized by the gradual dissolution of language functions, especially in the early stages of disorder. In a previous functional neuroimaging study, PPA patients were found to activate core language areas similarly to control subjects when performing semantic and phonological processing tasks (Sonty et al., 2003). In the present study, functional magnetic resonance imaging (fMRI) and dynamic causal modeling (DCM) were used to study multiregional effective connectivity in early-stage PPA (<jats:italic>n<\/jats:italic>= 8) and control (<jats:italic>n<\/jats:italic>= 8) subjects performing semantic word matching and visual letter matching tasks. fMRI analysis showed semantic task-specific activations in the left inferior frontal (Broca's area) and posterior superior temporal (Wernicke's area) regions, in addition to other language regions, in both groups. Using a model language network consisting of six left hemisphere regions, the DCM analysis demonstrated reduced language-specific effective connectivity between Wernicke's and Broca's areas in the PPA patient group. Furthermore, this decrement in connectivity was predictive of semantic task accuracy. These results demonstrate for the first time that dysfunctional network interactions (effective connectivity), rather than hypoactivity within individual brain regions, may contribute to the emergence of language deficits seen in PPA.<\/jats:p>","DOI":"10.1523\/jneurosci.4127-06.2007","type":"journal-article","created":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T23:15:04Z","timestamp":1170890104000},"page":"1334-1345","source":"Crossref","is-referenced-by-count":114,"title":["Altered Effective Connectivity within the Language Network in Primary Progressive Aphasia"],"prefix":"10.1523","volume":"27","author":[{"given":"Sreepadma P.","family":"Sonty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.-Marsel","family":"Mesulam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Weintraub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd B.","family":"Parrish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren R.","family":"Gitelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"393","published-online":{"date-parts":[[2007,2,7]]},"reference":[{"key":"2023041303232012000_27.6.1334.1","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050466"},{"key":"2023041303232012000_27.6.1334.2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0582"},{"key":"2023041303232012000_27.6.1334.3","unstructured":"Baddeley A (1994) in Memory systems 1994, Working memory: the interface between memory and cognition, eds Schacter DL Tulving E (MIT, Cambridge, MA), pp 351\u2013367."},{"key":"2023041303232012000_27.6.1334.4","unstructured":"Benton A Harnsher KdS Varney N Speen O (1998) Contributions to neuropsychological assessment (Oxford UP, New York)."},{"key":"2023041303232012000_27.6.1334.5","unstructured":"Benton AL Hamsher Kd Varney NR Spreen O (1983) Contributions to neuropsychological assessment (Oxford UP, New York)."},{"key":"2023041303232012000_27.6.1334.6","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(79)90053-8"},{"key":"2023041303232012000_27.6.1334.7","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0864-05.2005"},{"key":"2023041303232012000_27.6.1334.8","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.25.112701.142946"},{"key":"2023041303232012000_27.6.1334.9","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.10.1901"},{"key":"2023041303232012000_27.6.1334.10","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1136"},{"key":"2023041303232012000_27.6.1334.11","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10445"},{"key":"2023041303232012000_27.6.1334.12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/ana.20319","article-title":"Perisylvian language networks of the human brain","volume":"57","author":"Catani","year":"2004","journal-title":"Ann Neurol"},{"key":"2023041303232012000_27.6.1334.13","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0635"},{"key":"2023041303232012000_27.6.1334.14","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410190112"},{"key":"2023041303232012000_27.6.1334.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(03)00032-0"},{"key":"2023041303232012000_27.6.1334.16","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2005.857652"},{"key":"2023041303232012000_27.6.1334.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80855-7"},{"key":"2023041303232012000_27.6.1334.18","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/115.6.1753"},{"key":"2023041303232012000_27.6.1334.19","doi-asserted-by":"publisher","DOI":"10.1006\/brln.1996.0109"},{"key":"2023041303232012000_27.6.1334.20","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.6.1411"},{"key":"2023041303232012000_27.6.1334.21","doi-asserted-by":"publisher","DOI":"10.1162\/089892903321107837"},{"key":"2023041303232012000_27.6.1334.22","doi-asserted-by":"publisher","DOI":"10.1038\/427311a"},{"key":"2023041303232012000_27.6.1334.23","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4628-05.2006"},{"key":"2023041303232012000_27.6.1334.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.09.059"},{"key":"2023041303232012000_27.6.1334.25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/(SICI)1097-0193(1997)5:2<79::AID-HBM1>3.0.CO;2-J","article-title":"Phonology, semantics and the role of the left inferior prefrontal cortex","volume":"5","author":"Fiez","year":"1997","journal-title":"Hum Brain Mapp"},{"key":"2023041303232012000_27.6.1334.26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.3.914"},{"key":"2023041303232012000_27.6.1334.27","doi-asserted-by":"crossref","unstructured":"Fiez JA Raichle ME (1997) in The cerebellum and cognition, Linguistic processing, ed Schmahmann JD (Academic, San Diego), pp 233\u2013254.","DOI":"10.1016\/S0074-7742(08)60354-2"},{"key":"2023041303232012000_27.6.1334.28","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1162\/jocn.1995.7.3.357","article-title":"PET studies of auditory and phonological processing: effects of stimulus characteristics and task demands","volume":"7","author":"Fiez","year":"1995","journal-title":"J Cogn Neurosci"},{"key":"2023041303232012000_27.6.1334.29","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"2023041303232012000_27.6.1334.30","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/hbm.460020402","article-title":"Statistical parametric maps in functional imaging: a general linear approach","volume":"2","author":"Friston","year":"1995","journal-title":"Hum Brain Mapp"},{"key":"2023041303232012000_27.6.1334.31","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/hbm.460030303","article-title":"Spatial registration and normalization of images","volume":"3","author":"Friston","year":"1995","journal-title":"Hum Brain Mapp"},{"key":"2023041303232012000_27.6.1334.32","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1996.0074"},{"key":"2023041303232012000_27.6.1334.33","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00202-7"},{"key":"2023041303232012000_27.6.1334.34","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/88.2.237"},{"key":"2023041303232012000_27.6.1334.35","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.6.1093"},{"key":"2023041303232012000_27.6.1334.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.03.014"},{"key":"2023041303232012000_27.6.1334.37","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0786"},{"key":"2023041303232012000_27.6.1334.38","unstructured":"Goodglass H Kaplan EF (1983) The Boston Diagnostic Aphasia Examination (Lea and Febiger, Philadelphia)."},{"key":"2023041303232012000_27.6.1334.39","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10825"},{"key":"2023041303232012000_27.6.1334.40","doi-asserted-by":"publisher","DOI":"10.1162\/089892999563490"},{"key":"2023041303232012000_27.6.1334.41","unstructured":"Halstead W (1947) Brain and intelligence (University of Chicago, Chicago)."},{"key":"2023041303232012000_27.6.1334.42","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-934X(03)00349-3"},{"key":"2023041303232012000_27.6.1334.43","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90417-6"},{"key":"2023041303232012000_27.6.1334.44","unstructured":"Jenkinson M Pechaud M Smith SM (2005) BET2: MR-based estimation of brain, skull, and scalp surfaces. Paper presented at Eleventh International Conference on Functional Mapping of the Human Brain, Toronto, Ontario, Canada, June."},{"key":"2023041303232012000_27.6.1334.45","first-page":"223","article-title":"The Activities of Daily Living Questionnaire: a validation study in patients with dementia","volume":"18","author":"Johnson","year":"2004","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"2023041303232012000_27.6.1334.46","unstructured":"Kaplan E Goodglass H Weintraub S (1983) The Boston Naming Test (Lea and Febiger, Philadelphia)."},{"key":"2023041303232012000_27.6.1334.47","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1097\/00001756-199410270-00051","article-title":"The role of left prefrontal cortex in verbal processing: semantic processing or willed action?","volume":"5","author":"Kapur","year":"1994","journal-title":"NeuroReport"},{"key":"2023041303232012000_27.6.1334.48","unstructured":"Kertesz A (1982) Western Aphasia Battery (WAB) (The Psychological Corporation, San Antonio, TX)."},{"key":"2023041303232012000_27.6.1334.49","unstructured":"Kucera H Francis WN (1967) Computational analysis of present-day American English (Brown UP, Providence, RI)."},{"key":"2023041303232012000_27.6.1334.50","unstructured":"Macmillan N Creelman D (1991) Detection theory: a user's guide (Cambridge UP, Cambridge, UK)."},{"key":"2023041303232012000_27.6.1334.51","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5233.102"},{"key":"2023041303232012000_27.6.1334.52","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1231"},{"key":"2023041303232012000_27.6.1334.53","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410110607"},{"key":"2023041303232012000_27.6.1334.54","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/ana.410280502","article-title":"Large-scale neurocognitive networks and distributed processing for attention, language, and memory","volume":"28","author":"Mesulam","year":"1990","journal-title":"Ann Neurol"},{"key":"2023041303232012000_27.6.1334.55","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.6.1013"},{"key":"2023041303232012000_27.6.1334.56","doi-asserted-by":"publisher","DOI":"10.1002\/ana.91"},{"key":"2023041303232012000_27.6.1334.57","unstructured":"Mesulam M-M Weintraub S (1992) in Unusual dementias, Spectrum of primary progressive aphasia, ed Rossor MN (Bailli\u00e8re Tindall, London), pp 583\u2013609."},{"key":"2023041303232012000_27.6.1334.58","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90066-X"},{"key":"2023041303232012000_27.6.1334.59","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022435"},{"key":"2023041303232012000_27.6.1334.60","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1002\/ana.10569","article-title":"The core and halo of primary progressive aphasia and semantic dementia","volume":"54","author":"Mesulam","year":"2003","journal-title":"Ann Neurol"},{"key":"2023041303232012000_27.6.1334.61","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.9.1159"},{"key":"2023041303232012000_27.6.1334.62","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.1.61"},{"key":"2023041303232012000_27.6.1334.63","doi-asserted-by":"publisher","DOI":"10.1038\/372260a0"},{"key":"2023041303232012000_27.6.1334.64","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"2023041303232012000_27.6.1334.65","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1098\/rstb.1996.0127","article-title":"Comparison of prefrontal connections and architecture","volume":"351","author":"Pandya","year":"1996","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"2023041303232012000_27.6.1334.66","doi-asserted-by":"crossref","first-page":"S560","DOI":"10.1016\/S1053-8119(18)31393-4","article-title":"Clinical fMRI: is patient motion really an issue?","volume":"7","author":"Parrish","year":"1998","journal-title":"NeuroImage"},{"key":"2023041303232012000_27.6.1334.67","doi-asserted-by":"publisher","DOI":"10.1038\/362342a0"},{"key":"2023041303232012000_27.6.1334.68","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.1.143"},{"key":"2023041303232012000_27.6.1334.69","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199705260-00042"},{"key":"2023041303232012000_27.6.1334.70","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.03.026"},{"key":"2023041303232012000_27.6.1334.71","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.16.030193.002453"},{"key":"2023041303232012000_27.6.1334.72","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00518.x"},{"key":"2023041303232012000_27.6.1334.73","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1046\/j.1469-7580.2000.19730335.x","article-title":"The anatomy of language: contributions from functional neuroimaging","volume":"197","author":"Price","year":"2000","journal-title":"J Anat"},{"key":"2023041303232012000_27.6.1334.74","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1162\/08989290152001853","article-title":"Dynamic diaschisis: anatomically remote and context-sensitive human brain lesions","volume":"13","author":"Price","year":"2001","journal-title":"J Cogn Neurosci"},{"key":"2023041303232012000_27.6.1334.75","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/j.neuroimage.2003.09.012","article-title":"Normal and pathological reading: converging data from lesion and imaging studies","volume":"20","author":"Price","year":"2003","journal-title":"NeuroImage"},{"key":"2023041303232012000_27.6.1334.76","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90888-4"},{"key":"2023041303232012000_27.6.1334.77","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF00237280","article-title":"Further observations on parieto-temporal connections in the rhesus monkey","volume":"55","author":"Seltzer","year":"1984","journal-title":"Exp Brain Res"},{"key":"2023041303232012000_27.6.1334.78","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902900402"},{"key":"2023041303232012000_27.6.1334.79","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903430308"},{"key":"2023041303232012000_27.6.1334.80","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/BF00596535","article-title":"Neuroradiological findings in primary progressive aphasia: CT, MRI and cerebral perfusion SPECT","volume":"38","author":"Sinnathamby","year":"1996","journal-title":"Neuroradiology"},{"key":"2023041303232012000_27.6.1334.81","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10062"},{"key":"2023041303232012000_27.6.1334.82","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10390"},{"key":"2023041303232012000_27.6.1334.83","unstructured":"Talairach J Tournoux P (1988) Co-planar stereotaxic atlas of the human brain (Thieme Medical Publishers, New York)."},{"key":"2023041303232012000_27.6.1334.84","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/113.5.1321"},{"key":"2023041303232012000_27.6.1334.85","doi-asserted-by":"publisher","DOI":"10.1126\/science.1734518"},{"key":"2023041303232012000_27.6.1334.86","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5380.1188"},{"key":"2023041303232012000_27.6.1334.87","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/4.5.470"},{"key":"2023041303232012000_27.6.1334.88","unstructured":"Wechsler D (1987) Wechsler Memory Scale\u2014Revised Manual (Psychological Corporation, San Antonio, TX)."},{"key":"2023041303232012000_27.6.1334.89","doi-asserted-by":"publisher","DOI":"10.1006\/brln.1997.1840"},{"key":"2023041303232012000_27.6.1334.90","doi-asserted-by":"publisher","DOI":"10.1080\/13803390490510077"},{"key":"2023041303232012000_27.6.1334.91","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.1.83"},{"key":"2023041303232012000_27.6.1334.92","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1996)4:1<58::AID-HBM4>3.0.CO;2-O"},{"key":"2023041303232012000_27.6.1334.93","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a geriatric depression screening scale: a preliminary report","volume":"17","author":"Yesavage","year":"1983","journal-title":"J Psychiatr Res"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.4127-06.2007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T17:51:23Z","timestamp":1681408283000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.4127-06.2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,7]]},"references-count":93,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2007,2,7]]},"published-print":{"date-parts":[[2007,2,7]]}},"alternative-id":["10.1523\/JNEUROSCI.4127-06.2007"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.4127-06.2007","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,7]]}}}