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We assessed retrograde amnesia with the Autobiographical Memory Interview (AMI) and with a news events test in six patients with damage limited primarily to the hippocampal region (H group) and two patients with large medial temporal lobe lesions (MTL group). On the news event test, the H group exhibited temporally limited retrograde amnesia covering \u223c5 years. On the same test, the MTL group exhibited an extensive retrograde amnesia covering decades. Nevertheless, performance was relatively spared for very remote time periods. On the AMI, all patients had intact remote autobiographical memory. Because our patients with hippocampal lesions, as well as our patients with large MTL lesions, performed normally on the AMI, patients who perform poorly on the same test presumably have damage beyond the hippocampus and related structures in the medial temporal lobe. The findings emphasize the difference in the extent of retrograde amnesia associated with hippocampal lesions and large MTL lesions.<\/jats:p>","DOI":"10.1523\/jneurosci.4262-06.2006","type":"journal-article","created":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T17:28:11Z","timestamp":1166635691000},"page":"13311-13317","source":"Crossref","is-referenced-by-count":106,"title":["The Fate of Old Memories after Medial Temporal Lobe Damage"],"prefix":"10.1523","volume":"26","author":[{"given":"Peter J.","family":"Bayley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona O.","family":"Hopkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry 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