{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:24:44Z","timestamp":1792704284565,"version":"4.5.0"},"reference-count":40,"publisher":"Society for Neuroscience","issue":"7","license":[{"start":{"date-parts":[[2012,8,15]],"date-time":"2012-08-15T00:00:00Z","timestamp":1344988800000},"content-version":"vor","delay-in-days":183,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2012,2,15]]},"abstract":"<jats:p>Human genetic studies have revealed that neurokinin B (NKB) and its receptor, neurokinin-3 receptor (NK3R), are essential elements for normal reproduction; however, the precise role of NKB\u2013NK3R signaling in the initiation of puberty remains unknown. We investigated here the regulation of<jats:italic>Tac2<\/jats:italic>and<jats:italic>Tacr3<\/jats:italic>mRNAs (encoding NKB and NK3R, respectively) in female rats and demonstrated that their hypothalamic expression is increased along postnatal maturation. At puberty, both genes were widely expressed throughout the brain, including the lateral hypothalamic area and the arcuate nucleus (ARC)\/medial basal hypothalamus, where the expression of<jats:italic>Tacr3<\/jats:italic>increased across pubertal transition. We showed that central administration of senktide (NK3R agonist) induced luteinizing hormone (LH) secretion in prepubertal and peripubertal females. Conversely, chronic infusion of an NK3R antagonist during puberty moderately delayed the timing of vaginal opening (VO) and tended to decrease LH levels. The expression of NKB and its receptor was sensitive to changes in metabolic status during puberty, as reflected by a reduction in<jats:italic>Tacr3<\/jats:italic>(and, to a lesser extent,<jats:italic>Tac2<\/jats:italic>) expression in the ARC after a 48 h fast. Yet, acute LH responses to senktide in pubertal females were preserved, if not augmented, under fasting conditions, suggesting sensitization of the NKB\u2013NK3R\u2013gonadotropin-releasing hormone signaling pathway under metabolic distress. Moreover, repeated administration of senktide to female rats with pubertal arrest due to chronic undernutrition rescued VO (in \u223c50% of animals) and potently elicited LH release. Altogether, our observations suggest that NKB\u2013NK3R signaling plays a role in pubertal maturation and that its alterations may contribute to pubertal disorders linked to metabolic stress and negative energy balance.<\/jats:p>","DOI":"10.1523\/jneurosci.4288-11.2012","type":"journal-article","created":{"date-parts":[[2012,2,14]],"date-time":"2012-02-14T17:25:39Z","timestamp":1329240339000},"page":"2388-2397","source":"Crossref","is-referenced-by-count":154,"title":["Role of Neurokinin B in the Control of Female Puberty and Its Modulation by Metabolic Status"],"prefix":"10.1523","volume":"32","author":[{"given":"V\u00edctor M.","family":"Navarro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Ruiz-Pino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel 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