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Adult mice were subjected to a unilateral photothrombotic stroke of the right motor cortex ablating 90% of the cross-projecting corticospinal cells. Unilateral retrograde tracing from the left cervical spinal hemicord devoid of its corticospinal input revealed widespread plastic responses in different brainstem nuclei 4 weeks after stroke. Whereas some nuclei showed no change or a decrease of their spinal projections, several parts of the medullary reticular formation as well as the spinally projecting raphe nuclei increased their projections to the cortically denervated cervical hemicord by 1.2- to 1.6-fold. The terminal density of corticobulbar fibers from the intact, contralesional cortex, which itself formed a fivefold expanded connection to the ipsilateral spinal cord, increased up to 1.6-fold specifically in these plastic, caudal medullary nuclei. A second stroke, ablating the originally spared motor cortex, resulted in the reappearance of the deficits that had partially recovered after the initial right-sided stroke, suggesting dependence of recovered function on the spared cortical hemisphere and its direct corticospinal and indirect corticobulbospinal connections.<\/jats:p>","DOI":"10.1523\/jneurosci.4384-13.2014","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T17:23:41Z","timestamp":1393435421000},"page":"3378-3389","source":"Crossref","is-referenced-by-count":70,"title":["Sprouting of Brainstem\u2013Spinal Tracts in Response to Unilateral Motor Cortex Stroke in Mice"],"prefix":"10.1523","volume":"34","author":[{"given":"Lukas C.","family":"Bachmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas 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