{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:48:36Z","timestamp":1791388116005,"version":"4.3.3"},"reference-count":59,"publisher":"Society for Neuroscience","issue":"15","license":[{"start":{"date-parts":[[2007,10,11]],"date-time":"2007-10-11T00:00:00Z","timestamp":1192060800000},"content-version":"vor","delay-in-days":183,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2007,4,11]]},"abstract":"<jats:p>Voltage-gated Na<jats:sup>+<\/jats:sup>(Na<jats:sub>v<\/jats:sub>) channels are highly concentrated at nodes of Ranvier in myelinated axons and facilitate rapid action potential conduction. Autoantibodies to gangliosides such as GM1 have been proposed to disrupt nodal Nav channels and lead to Guillain-Barr\u00e9 syndrome, an autoimmune neuropathy characterized by acute limb weakness. To test this hypothesis, we examined the molecular organization of nodes in a disease model caused by immunization with gangliosides. At the acute phase with progressing limb weakness, Na<jats:sub>v<\/jats:sub>channel clusters were disrupted or disappeared at abnormally lengthened nodes concomitant with deposition of IgG and complement products. Paranodal axoglial junctions, the nodal cytoskeleton, and Schwann cell microvilli, all of which stabilize Na<jats:sub>v<\/jats:sub>channel clusters, were also disrupted. The nodal molecules disappeared in lesions with complement deposition but no localization of macrophages. During recovery, complement deposition at nodes decreased, and Na<jats:sub>v<\/jats:sub>channels redistributed on both sides of affected nodes. These results suggest that Na<jats:sub>v<\/jats:sub>channel alterations occur as a consequence of complement-mediated disruption of interactions between axons and Schwann cells. Our findings support the idea that acute motor axonal neuropathy is a disease that specifically disrupts the nodes of Ranvier.<\/jats:p>","DOI":"10.1523\/jneurosci.4401-06.2007","type":"journal-article","created":{"date-parts":[[2007,4,11]],"date-time":"2007-04-11T16:58:06Z","timestamp":1176310686000},"page":"3956-3967","source":"Crossref","is-referenced-by-count":331,"title":["Anti-GM1 Antibodies Cause Complement-Mediated Disruption of Sodium Channel Clusters in Peripheral Motor Nerve Fibers"],"prefix":"10.1523","volume":"27","author":[{"given":"Keiichiro","family":"Susuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew N.","family":"Rasband","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koujiro","family":"Tohyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsura","family":"Koibuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Funakoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Baba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Yuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2007,4,11]]},"reference":[{"key":"2023041303245094000_27.15.3956.1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20321"},{"key":"2023041303245094000_27.15.3956.2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.5.985"},{"key":"2023041303245094000_27.15.3956.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00294-X"},{"key":"2023041303245094000_27.15.3956.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.12.005"},{"key":"2023041303245094000_27.15.3956.5","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21004"},{"key":"2023041303245094000_27.15.3956.6","first-page":"421","article-title":"Bonferroni inequalities and intervals","volume-title":"Encyclopedia of biostatistics","volume":"Vol 1","author":"Costigan","year":"1998"},{"key":"2023041303245094000_27.15.3956.7","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3328-04.2005"},{"key":"2023041303245094000_27.15.3956.8","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1523\/JNEUROSCI.15-01-00492.1995","article-title":"Clustering of Na+ channels and node of Ranvier formation in remyelinating axons","volume":"15","author":"Dugandz\u0306ija-Novakovi\u0107","year":"1995","journal-title":"J Neurosci"},{"key":"2023041303245094000_27.15.3956.9","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.139.6.1495"},{"key":"2023041303245094000_27.15.3956.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.06.026"},{"key":"2023041303245094000_27.15.3956.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(01)00055-4"},{"key":"2023041303245094000_27.15.3956.12","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4279-04.2005"},{"key":"2023041303245094000_27.15.3956.13","doi-asserted-by":"publisher","DOI":"10.1007\/BF02284784"},{"key":"2023041303245094000_27.15.3956.14","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390512"},{"key":"2023041303245094000_27.15.3956.15","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400414"},{"key":"2023041303245094000_27.15.3956.16","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh231"},{"key":"2023041303245094000_27.15.3956.17","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20546"},{"key":"2023041303245094000_27.15.3956.18","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.12.2159"},{"key":"2023041303245094000_27.15.3956.19","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67665-9"},{"key":"2023041303245094000_27.15.3956.20","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70041-7"},{"key":"2023041303245094000_27.15.3956.21","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200110003"},{"key":"2023041303245094000_27.15.3956.22","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199907)22:7<840::AID-MUS5>3.0.CO;2-2"},{"key":"2023041303245094000_27.15.3956.23","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10275"},{"key":"2023041303245094000_27.15.3956.24","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10488"},{"key":"2023041303245094000_27.15.3956.25","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200408007"},{"key":"2023041303245094000_27.15.3956.26","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/73.1.13"},{"key":"2023041303245094000_27.15.3956.27","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25466"},{"key":"2023041303245094000_27.15.3956.28","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80942-3"},{"key":"2023041303245094000_27.15.3956.29","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018571711014"},{"key":"2023041303245094000_27.15.3956.30","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(98)00311-6"},{"key":"2023041303245094000_27.15.3956.31","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1212\/01.WNL.0000129917.28461.0C","article-title":"Immunoglobulin improves a model of acute motor axonal neuropathy by preventing axonal degeneration","volume":"62","author":"Nishimoto","year":"2004","journal-title":"Neurology"},{"key":"2023041303245094000_27.15.3956.32","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199808)21:8<1019::AID-MUS6>3.0.CO;2-B"},{"key":"2023041303245094000_27.15.3956.33","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/01.wco.0000173284.25581.2f","article-title":"Recent developments in Miller Fisher syndrome and related disorders","volume":"18","author":"Overell","year":"2005","journal-title":"Curr Opin Neurol"},{"key":"2023041303245094000_27.15.3956.34","doi-asserted-by":"publisher","DOI":"10.1007\/BF01069750"},{"key":"2023041303245094000_27.15.3956.35","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.5.807"},{"key":"2023041303245094000_27.15.3956.36","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.5.978"},{"key":"2023041303245094000_27.15.3956.37","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-005-0004-1"},{"key":"2023041303245094000_27.15.3956.38","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/nrn1253","article-title":"The local differentiation of myelinated axons at nodes of Ranvier","volume":"4","author":"Poliak","year":"2003","journal-title":"Nat Rev Neurosci"},{"key":"2023041303245094000_27.15.3956.39","doi-asserted-by":"crossref","first-page":"7516","DOI":"10.1523\/JNEUROSCI.19-17-07516.1999","article-title":"Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS","volume":"19","author":"Rasband","year":"1999","journal-title":"J Neurosci"},{"key":"2023041303245094000_27.15.3956.40","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.1523\/JNEUROSCI.23-18-07001.2003","article-title":"Paranodal interactions regulate expression of sodium channel subtypes and provide a diffusion barrier for the node of Ranvier","volume":"23","author":"Rios","year":"2003","journal-title":"J Neurosci"},{"key":"2023041303245094000_27.15.3956.41","doi-asserted-by":"publisher","DOI":"10.1080\/07853890510007278"},{"key":"2023041303245094000_27.15.3956.42","doi-asserted-by":"publisher","DOI":"10.1017\/S1740925X06000093"},{"key":"2023041303245094000_27.15.3956.43","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.1138"},{"key":"2023041303245094000_27.15.3956.44","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.3.449"},{"key":"2023041303245094000_27.15.3956.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.10.019"},{"key":"2023041303245094000_27.15.3956.46","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300205"},{"key":"2023041303245094000_27.15.3956.47","doi-asserted-by":"publisher","DOI":"10.1007\/s004150170253"},{"key":"2023041303245094000_27.15.3956.48","doi-asserted-by":"publisher","DOI":"10.1002\/ana.33333"},{"key":"2023041303245094000_27.15.3956.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.06.059"},{"key":"2023041303245094000_27.15.3956.50","doi-asserted-by":"crossref","unstructured":"Susuki K Baba H Tohyama K Kanai K Kuwabara S Hirata K Furukawa K Furukawa K Rasband MN Yuki N (2007) Gangliosides contribute to stability of paranodal junctions and ion channel clusters in myelinated nerve fibers. Glia, in press.","DOI":"10.1002\/glia.20503"},{"key":"2023041303245094000_27.15.3956.51","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370405"},{"key":"2023041303245094000_27.15.3956.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2003.09.015"},{"key":"2023041303245094000_27.15.3956.53","doi-asserted-by":"crossref","first-page":"4914","DOI":"10.1523\/JNEUROSCI.16-16-04914.1996","article-title":"The clustering of axonal sodium channels during development of the peripheral nervous system","volume":"16","author":"Vabnick","year":"1996","journal-title":"J Neurosci"},{"key":"2023041303245094000_27.15.3956.54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.10.005"},{"key":"2023041303245094000_27.15.3956.55","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370403"},{"key":"2023041303245094000_27.15.3956.56","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2125-04.2004"},{"key":"2023041303245094000_27.15.3956.57","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2005.09.004"},{"key":"2023041303245094000_27.15.3956.58","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1012"},{"key":"2023041303245094000_27.15.3956.59","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402391101"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.4401-06.2007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T18:00:01Z","timestamp":1681408801000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.4401-06.2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,11]]},"references-count":59,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2007,4,11]]},"published-print":{"date-parts":[[2007,4,11]]}},"alternative-id":["10.1523\/JNEUROSCI.4401-06.2007"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.4401-06.2007","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,11]]}}}