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Mice were reared either in a deprived environment and subsequently housed in deprived, minimally enriched, or enriched conditions after the removal of the c-row of vibrissae or reared in an enriched environment before and after vibrissae removal. Levels of vesicular zinc were assessed in deprived and nondeprived barrels 6 h to 14 d after vibrissae removal. We found that housing in enriched environmental conditions resulted in a greater change in vesicular zinc levels than did other housing conditions; however, this effect was dependent on both the magnitude and duration of enrichment. Our data indicate that enriched-environment housing has profound effects on the regulation of vesicular zinc that occurs concurrently with experience-dependent plasticity, suggesting a role for zinc in the multitude of cortical modifications associated with enriched environments.<\/jats:p>","DOI":"10.1523\/jneurosci.4645-08.2008","type":"journal-article","created":{"date-parts":[[2008,12,17]],"date-time":"2008-12-17T17:23:20Z","timestamp":1229534600000},"page":"13995-13999","source":"Crossref","is-referenced-by-count":16,"title":["Enhanced Plasticity in Zincergic, Cortical Circuits after Exposure to Enriched Environments"],"prefix":"10.1523","volume":"28","author":[{"given":"Amy S.","family":"Nakashima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard 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