{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:24:21Z","timestamp":1791354261662,"version":"4.3.1"},"reference-count":48,"publisher":"Society for Neuroscience","issue":"4","license":[{"start":{"date-parts":[[2005,7,26]],"date-time":"2005-07-26T00:00:00Z","timestamp":1122336000000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2005,1,26]]},"abstract":"<jats:p>Ribeye is the only known protein specific to synaptic ribbon, but its function is unclear. We show that the teleost fish,<jats:italic>Fugu<\/jats:italic>and zebrafish, have two<jats:italic>ribeye<\/jats:italic>genes,<jats:italic>ribeye a<\/jats:italic>and ribeye<jats:italic>b<\/jats:italic>. Whole-mount<jats:italic>in situ<\/jats:italic>hybridization revealed that<jats:italic>ribeye a<\/jats:italic>is expressed in tissues containing synaptic ribbons, including the pineal gland, inner ear, and retina.<jats:italic>Ribeye b<\/jats:italic>is absent in the pineal gland. In the retina,<jats:italic>ribeye a<\/jats:italic>is expressed in both photoreceptors and bipolar cells, whereas<jats:italic>ribeye b<\/jats:italic>is detected only in photoreceptors. To study the function of Ribeye a in retina, we depleted it by morpholino antisense oligos. Fish deficient in Ribeye a lack an optokinetic response and have shorter synaptic ribbons in photoreceptors and fewer synaptic ribbons in bipolar cells. Their bipolar cells still target Syntaxin-3 proteins to the inner plexiform layer and have abundant<jats:italic>vsx1<\/jats:italic>mRNA. However, they lack large synaptic terminals and show increased apoptosis. Rod bipolar cells are fewer in number and\/or deficient in PKC\u03b1. Recovery of Ribeye a levels rescues the optokinetic response, increases the number of PKC\u03b1-positive bipolar cells, and stops apoptosis. We conclude that Ribeye a is important for late steps in bipolar cell development.<\/jats:p>","DOI":"10.1523\/jneurosci.4657-04.2005","type":"journal-article","created":{"date-parts":[[2005,1,27]],"date-time":"2005-01-27T03:05:19Z","timestamp":1106795119000},"page":"941-949","source":"Crossref","is-referenced-by-count":78,"title":["Two<i>ribeye<\/i>Genes in Teleosts: The Role of Ribeye in Ribbon Formation and Bipolar Cell 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