{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:55:25Z","timestamp":1791165325209,"version":"4.1.0"},"reference-count":48,"publisher":"Society for Neuroscience","issue":"12","license":[{"start":{"date-parts":[[2010,9,24]],"date-time":"2010-09-24T00:00:00Z","timestamp":1285286400000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2010,3,24]]},"abstract":"<jats:p>Hydroxy-\u03b1-sanshool, the active ingredient in plants of the prickly ash plant family, induces robust tingling paresthesia by activating a subset of somatosensory neurons. However, the subtypes and physiological function of sanshool-sensitive neurons remain unknown. Here we use the<jats:italic>ex vivo<\/jats:italic>skin\u2013nerve preparation to examine the pattern and intensity with which the sensory terminals of cutaneous neurons respond to hydroxy-\u03b1-sanshool. We found that sanshool excites virtually all D-hair afferents, a distinct subset of ultrasensitive light-touch receptors in the skin and targets novel populations of A\u03b2 and C fiber nerve afferents. Thus, sanshool provides a novel pharmacological tool for discriminating functional subtypes of cutaneous mechanoreceptors. The identification of sanshool-sensitive fibers represents an essential first step in identifying the cellular and molecular mechanisms underlying tingling paresthesia that accompanies peripheral neuropathy and injury.<\/jats:p>","DOI":"10.1523\/jneurosci.4666-09.2010","type":"journal-article","created":{"date-parts":[[2010,3,24]],"date-time":"2010-03-24T17:08:00Z","timestamp":1269450480000},"page":"4353-4361","source":"Crossref","is-referenced-by-count":84,"title":["Physiological Basis of Tingling Paresthesia Evokedby Hydroxy-\u03b1-Sanshool"],"prefix":"10.1523","volume":"30","author":[{"given":"Richard C.","family":"Lennertz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Tsunozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana 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