{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:02:19Z","timestamp":1792738939104,"version":"4.5.0"},"reference-count":61,"publisher":"Society for Neuroscience","issue":"5","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2006,2,1]]},"abstract":"<jats:p>\n                    Forward locomotion of\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    larvae is composed of rhythmic waves of contractions that are thought to be produced by segmentally organized central pattern generators. We present a systematic description of spike activity patterns during locomotive contraction waves in semi-intact wild-type and mutant larval preparations. We have shown previously that\n                    <jats:italic>\n                      T\u03b2h\n                      <jats:sup>nM18<\/jats:sup>\n                    <\/jats:italic>\n                    mutants, with altered levels of octopamine and tyramine, have a locomotion deficit. By recording\n                    <jats:italic>en passant<\/jats:italic>\n                    from the segmental nerves, we investigated the coordination of the neuronal activity driving contraction waves of the abdominal body-wall muscles. Rhythmic bursts of activity that occurred concurrently with locomotive waves were frequently observed in wild-type larvae but were rarely seen in\n                    <jats:italic>\n                      T\u03b2h\n                      <jats:sup>nM18<\/jats:sup>\n                    <\/jats:italic>\n                    mutants. These centrally generated patterned activities were eliminated in the distal stumps of both wild-type and\n                    <jats:italic>\n                      T\u03b2h\n                      <jats:sup>nM18<\/jats:sup>\n                    <\/jats:italic>\n                    larvae after severing the segmental nerve from the CNS. Patterned activities persisted in the proximal stumps deprived of sensory feedback from the periphery. Simultaneous recordings demonstrated a delay in the bursting activity between different segments, with greater delay for segments that were farther apart. In contrast, bilateral recordings within a single segment revealed a well synchronized activity pattern in nerves innervating each hemisegment in both wild-type and\n                    <jats:italic>\n                      T\u03b2h\n                      <jats:sup>nM18<\/jats:sup>\n                    <\/jats:italic>\n                    larvae. Significantly, rhythmic patterns of bursts and waves could be evoked in\n                    <jats:italic>\n                      T\u03b2h\n                      <jats:sup>nM18<\/jats:sup>\n                    <\/jats:italic>\n                    mutants by head or tail stimulation despite their highly irregular spontaneous activities. These observations suggest a role of the biogenic amines in the initiation and modulation of motor pattern generation. The technique presented here can be readily extended to examine the locomotion motor program of other mutants.\n                  <\/jats:p>","DOI":"10.1523\/jneurosci.4749-05.2006","type":"journal-article","created":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T19:13:40Z","timestamp":1138821220000},"page":"1486-1498","source":"Crossref","is-referenced-by-count":166,"title":["Coordination and Modulation of Locomotion Pattern Generators in\n                    <i>Drosophila<\/i>\n                    Larvae: Effects of Altered Biogenic Amine Levels by the Tyramine \u03b2 Hydroxlyase Mutation"],"prefix":"10.1523","volume":"26","author":[{"given":"Lyle E.","family":"Fox","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Soll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Fang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2006,2,1]]},"reference":[{"key":"2023041303163904000_26.5.1486.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.02.024"},{"key":"2023041303163904000_26.5.1486.2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3581"},{"key":"2023041303163904000_26.5.1486.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00359-002-0279-9"},{"key":"2023041303163904000_26.5.1486.4","doi-asserted-by":"publisher","DOI":"10.1007\/s003590000160"},{"key":"2023041303163904000_26.5.1486.5","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1910(94)00113-U"},{"key":"2023041303163904000_26.5.1486.6","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-01-00144.1993"},{"key":"2023041303163904000_26.5.1486.7","doi-asserted-by":"publisher","DOI":"10.3109\/01677069109167432"},{"key":"2023041303163904000_26.5.1486.8","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-11-03754.1990"},{"key":"2023041303163904000_26.5.1486.9","doi-asserted-by":"publisher","DOI":"10.1101\/lm.60203"},{"key":"2023041303163904000_26.5.1486.10","doi-asserted-by":"publisher","DOI":"10.1002\/neu.1042"},{"key":"2023041303163904000_26.5.1486.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-0491(98)10160-8"},{"key":"2023041303163904000_26.5.1486.12","first-page":"449","volume":"2","year":"(1978)","journal-title":"In: The genetics and biology of Drosophila"},{"key":"2023041303163904000_26.5.1486.13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1242\/jeb.121.1.115","volume":"121","year":"(1986)","journal-title":"J Exp Biol"},{"key":"2023041303163904000_26.5.1486.14","doi-asserted-by":"publisher","DOI":"10.1007\/s003590000117"},{"key":"2023041303163904000_26.5.1486.15","doi-asserted-by":"crossref","unstructured":"Fox LE, Ueda A, Berke B, Peng IF, Wu CF (2004) Movement disorders in Drosophila mutants of potassium channels and biogenic amine pathways. 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