{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:30:10Z","timestamp":1791275410080,"version":"4.1.0"},"reference-count":61,"publisher":"Society for Neuroscience","issue":"7","license":[{"start":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T00:00:00Z","timestamp":1092787200000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2004,2,18]]},"abstract":"<jats:p>\n                    Glutamate release from rod photoreceptors is dependent on a sustained calcium influx through L-type calcium channels. Missense mutations in the\n                    <jats:italic>CACNA1F<\/jats:italic>\n                    gene in patients with incomplete X-linked congenital stationary night blindness implicate the Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.4 calcium channel subtype. Here, we describe the functional and pharmacological properties of transiently expressed human Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.4 calcium channels. Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.4 is shown to encode a dihydropyridine-sensitive calcium channel with unusually slow inactivation kinetics that are not affected by either calcium ions or by coexpression of ancillary calcium channel \u03b2 subunits. Additionally, the channel supports a large window current and activates near -40 mV in 2 mM external calcium, making Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.4 ideally suited for tonic calcium influx at typical photoreceptor resting potentials. Introduction of base pair changes associated with four incomplete X-linked congenital night blindness mutations showed that only the G369D alteration affected channel activation properties. Immunohistochemical analyses show that, in contrast with previous reports, Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.4 is widely distributed outside the retina, including in the immune system, thus suggesting a broader role in human physiology.\n                  <\/jats:p>","DOI":"10.1523\/jneurosci.4846-03.2004","type":"journal-article","created":{"date-parts":[[2004,2,18]],"date-time":"2004-02-18T15:02:48Z","timestamp":1077116568000},"page":"1707-1718","source":"Crossref","is-referenced-by-count":160,"title":["The\n                    <i>CACNA1F<\/i>\n                    Gene Encodes an L-Type Calcium Channel with Unique Biophysical Properties and Tissue Distribution"],"prefix":"10.1523","volume":"24","author":[{"given":"John E.","family":"McRory","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawed","family":"Hamid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clinton J.","family":"Doering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Hamming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hildebrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Beedle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Feldcamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald W.","family":"Zamponi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrance P.","family":"Snutch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2004,2,18]]},"reference":[{"key":"2023041303052286000_24.7.1707.1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1523\/JNEUROSCI.20-03-00929.2000","volume":"20","year":"2000","journal-title":"J Neurosci"},{"key":"2023041303052286000_24.7.1707.2","first-page":"1595","volume":"43","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2023041303052286000_24.7.1707.3","doi-asserted-by":"crossref","first-page":"5120","DOI":"10.4049\/jimmunol.161.10.5120","volume":"161","year":"1998","journal-title":"J Immunol"},{"key":"2023041303052286000_24.7.1707.4","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.10.1649"},{"key":"2023041303052286000_24.7.1707.5","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2001.790103.x"},{"key":"2023041303052286000_24.7.1707.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(02)00086-X"},{"key":"2023041303052286000_24.7.1707.7","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90072-8"},{"key":"2023041303052286000_24.7.1707.8","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.94.4.719"},{"key":"2023041303052286000_24.7.1707.9","unstructured":"Barnes S, Kelly M (2004) Voltage-gated Ca channels of the vertebrate retina: from the genetics of blindness to encoding the visual world. 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