{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:08:08Z","timestamp":1791036488794,"version":"4.1.0"},"reference-count":101,"publisher":"Society for Neuroscience","issue":"52","license":[{"start":{"date-parts":[[2009,6,24]],"date-time":"2009-06-24T00:00:00Z","timestamp":1245801600000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2008,12,24]]},"abstract":"<jats:p>Hippocampal area CA3 is critically involved in the formation of nonoverlapping neuronal subpopulations (\u201cpattern separation\u201d) to store memory representations as distinct events. Efficient pattern separation relies on the strong and sparse excitatory input from the mossy fibers (MFs) to pyramidal cells and feedforward inhibitory interneurons. However, MF synapses on CA3 pyramidal cells undergo long-term potentiation (LTP), which, if unopposed, will degrade pattern separation because MF activation will now recruit additional CA3 pyramidal cells. Here, we demonstrate MF LTP in stratum lacunosum-moleculare (L-M) interneurons induced by the same stimulation protocol that induces MF LTP in pyramidal cells. This LTP was NMDA receptor (NMDAR) independent and occurred at MF Ca<jats:sup>2+<\/jats:sup>-impermeable AMPA receptor synapses. LTP was prevented by with voltage clamping the postsynaptic cell soma during high-frequency stimulation (HFS), intracellular injections of the Ca<jats:sup>2+<\/jats:sup>chelator BAPTA (20 m<jats:sc>m<\/jats:sc>), or bath applications of the L-type Ca<jats:sup>2+<\/jats:sup>channel blocker nimodipine (10 \u03bc<jats:sc>m<\/jats:sc>). We propose that MF LTP in L-M interneurons preserves the sparsity of pyramidal cell activation, thus allowing CA3 to maintain its role in pattern separation. In the presence of the mGluR1\u03b1 antagonist LY367385 [(<jats:italic>S<\/jats:italic>)-(+)-<jats:italic>a<\/jats:italic>-amino-4-carboxy-2-methylbenzeneacetic acid] (100 \u03bc<jats:sc>m<\/jats:sc>), the same HFS that induces MF LTP in naive slices triggered NMDAR-independent MF LTD. This LTD, like LTP, required activation of the L-type Ca<jats:sup>2+<\/jats:sup>channel and also was induced after blockade of IP<jats:sub>3<\/jats:sub>receptors with heparin (4 mg\/ml) or the selective depletion of receptor-gated Ca<jats:sup>2+<\/jats:sup>stores with ryanodine (10 or 100 \u03bc<jats:sc>m<\/jats:sc>). We conclude that L-M interneurons are endowed with Ca<jats:sup>2+<\/jats:sup>signaling cascades suitable for controlling the polarity of MF long-term plasticity induced by joint presynaptic and postsynaptic activities.<\/jats:p>","DOI":"10.1523\/jneurosci.4848-08.2008","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T17:27:53Z","timestamp":1230139673000},"page":"14042-14055","source":"Crossref","is-referenced-by-count":55,"title":["Bidirectional Hebbian Plasticity at Hippocampal Mossy Fiber Synapses on CA3 Interneurons"],"prefix":"10.1523","volume":"28","author":[{"given":"Emilio 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