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Here we show that rats exposed to GAs at postnatal day 7 display a lasting reduction in inhibitory synaptic transmission, an increase in excitatory synaptic transmission, and concomitant increase in the amplitude of T-type calcium currents (T-currents) in neurons of the nucleus reticularis thalami (nRT). Collectively, this plasticity of ionic currents leads to increased action potential firing<jats:italic>in vitro<\/jats:italic>and increased strength of pharmacologically induced spike and wave discharges<jats:italic>in vivo<\/jats:italic>. Selective blockade of T-currents reversed neuronal hyperexcitability<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>. We conclude that drugs that regulate thalamic excitability may improve the safety of GAs used during early brain development.<\/jats:p>","DOI":"10.1523\/jneurosci.4883-13.2015","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T17:32:26Z","timestamp":1422466346000},"page":"1481-1492","source":"Crossref","is-referenced-by-count":31,"title":["Hyperexcitability of Rat Thalamocortical Networks after Exposure to General Anesthesia during Brain Development"],"prefix":"10.1523","volume":"35","author":[{"given":"Michael R.","family":"DiGruccio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srdjan","family":"Joksimovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavle 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