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It is shown here, with data from three experiments, that multimodal, local sensory cues can change the directional properties of CA1 pyramidal cells, inducing bidirectionality in a significant proportion of place cells. For a majority of these bidirectional place cells, place field centers in the two directions of motion were displaced relative to one another, as would be the case if the cells were representing a position in space \u223c5-10 cm ahead of the rat or if place cells were subject to strong accommodation or inhibition in the latter half of their input fields. However, place field density was not affected by the presence of local cues, but in the experimental condition with the most salient sensory cues, the CA1 population vectors in the \u201ccue-rich\u201d condition were sparser and changed more quickly in space than in the \u201ccue-poor\u201d condition. These results suggest that \u201cview-invariant\u201d object representations are projected to the hippocampus from lower cortical areas and can have the effect of increasing the correlation of the hippocampal input vectors in the two directions, hence decreasing the orthogonality of hippocampal output.<\/jats:p>","DOI":"10.1523\/jneurosci.4896-03.2004","type":"journal-article","created":{"date-parts":[[2004,5,12]],"date-time":"2004-05-12T16:02:55Z","timestamp":1084377775000},"page":"4541-4550","source":"Crossref","is-referenced-by-count":180,"title":["Local Sensory Cues and Place Cell Directionality: Additional Evidence of Prospective Coding in the Hippocampus"],"prefix":"10.1523","volume":"24","author":[{"given":"Francesco P.","family":"Battaglia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary R.","family":"Sutherland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"McNaughton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2004,5,12]]},"reference":[{"key":"2023041303064160000_24.19.4541.1","doi-asserted-by":"publisher","DOI":"10.1038\/40859"},{"key":"2023041303064160000_24.19.4541.2","first-page":"678.12","volume":"28","year":"2002","journal-title":"Soc Neurosci Abstr"},{"key":"2023041303064160000_24.19.4541.3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.459"},{"key":"2023041303064160000_24.19.4541.4","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.450010207"},{"key":"2023041303064160000_24.19.4541.5","unstructured":"Bower MR (2003) The neural basis of trajectory computations in rodent-posterior-parietal cortex and hippocampus. 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