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This replication-competent virus, the glioma-adapted vesicular stomatis virus strain VSVrp30a, was used for<jats:italic>in vivo<\/jats:italic>tests with the underlying view that infection of tumor cells will lead to an increase in the number of viruses subsequently released to kill additional tumor cells. Intravenous injection of VSVrp30a expressing a green fluorescent protein reporter, rapidly targeted and destroyed multiple types of human and mouse tumors implanted in the mouse brain, including glioblastoma and mammary tumors. When tumors were implanted both in the brain and peripherally, emulating systemic cancer metastasis, tumors inside and outside the brain were simultaneously infected. Intranasal inoculation, leading to olfactory nerve transport of the virus into the brain, selectively infected and killed olfactory bulb tumors. Neither control cortical wounds nor transplanted normal mouse or human cells were targeted, indicating viral tumor selectivity. Control viruses, including pseudorabies, adeno-associated, or replication-deficient VSV, did not infect the brain tumor. Confocal laser time-lapse imaging through a cranial window showed that intravenous VSV infects the tumor at multiple sites and kills migrating tumor cells. Disrupted tumor vasculature, suggested by dye leakage, may be the port of entry for intravenously delivered VSV. Quantitative PCR analysis of how VSVrp30a selectively infected tumor cells suggested multiple mechanisms, including cell surface binding and internalization.<\/jats:p>","DOI":"10.1523\/jneurosci.4905-07.2008","type":"journal-article","created":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T18:49:12Z","timestamp":1203619752000},"page":"1882-1893","source":"Crossref","is-referenced-by-count":76,"title":["Systemic Vesicular Stomatitis Virus Selectively Destroys Multifocal Glioma and Metastatic Carcinoma in Brain"],"prefix":"10.1523","volume":"28","author":[{"given":"Koray","family":"\u00d6zduman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Wollmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph M.","family":"Piepmeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony N.","family":"van den Pol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"393","published-online":{"date-parts":[[2008,2,20]]},"reference":[{"key":"2023041303301481000_28.8.1882.1","first-page":"419","article-title":"Viral vectors as therapeutic agents for glioblastoma","volume":"7","author":"Aghi","year":"2005","journal-title":"Curr Opin Mol Ther"},{"key":"2023041303301481000_28.8.1882.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.08.039"},{"key":"2023041303301481000_28.8.1882.3","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00330-1"},{"key":"2023041303301481000_28.8.1882.4","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.7.3474-3479.2001"},{"key":"2023041303301481000_28.8.1882.5","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209042"},{"key":"2023041303301481000_28.8.1882.6","unstructured":"Central Brain Tumor Registry of the United States (2005) Statistical report: primary brain tumors in the United States, 1998\u20132002 (Central Brain Tumor Registry of the United States, Chicago)."},{"key":"2023041303301481000_28.8.1882.7","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01911-06"},{"key":"2023041303301481000_28.8.1882.8","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.17.8960-8970.2004"},{"key":"2023041303301481000_28.8.1882.9","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2000.0736"},{"key":"2023041303301481000_28.8.1882.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101113440207"},{"key":"2023041303301481000_28.8.1882.11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7700794"},{"key":"2023041303301481000_28.8.1882.12","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.10.5740-5748.2003"},{"key":"2023041303301481000_28.8.1882.13","doi-asserted-by":"publisher","DOI":"10.1038\/nrc795"},{"key":"2023041303301481000_28.8.1882.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.10.026"},{"key":"2023041303301481000_28.8.1882.15","doi-asserted-by":"publisher","DOI":"10.1038\/78638"},{"key":"2023041303301481000_28.8.1882.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2004.03.003"},{"key":"2023041303301481000_28.8.1882.17","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2871"},{"key":"2023041303301481000_28.8.1882.18","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj413"},{"key":"2023041303301481000_28.8.1882.19","unstructured":"Lyles DS Rupprecht CE (2007) in Fields Virology, Rhabdoviridae, eds Knipe D. 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