{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:27:05Z","timestamp":1790731625257,"version":"4.1.0"},"reference-count":14,"publisher":"Society for Neuroscience","issue":"3","license":[{"start":{"date-parts":[[2004,7,21]],"date-time":"2004-07-21T00:00:00Z","timestamp":1090368000000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2004,1,21]]},"abstract":"<jats:p>Recent animal models suggest that disturbances in serotonin type-1A receptor (5-HT<jats:sub>1A<\/jats:sub>R) function may contribute to chronic anxiety, although it is not clear at all whether such models constitute relevant models for panic disorder (PD) in humans. The selective 5-HT<jats:sub>1A<\/jats:sub>R radioligand [18F]trans-4-fluoro-<jats:italic>N<\/jats:italic>-2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-<jats:italic>N<\/jats:italic>-(2-pyridyl)cyclohexanecarboxamide (FCWAY) permits<jats:italic>in vivo<\/jats:italic>assessment of central 5-HT<jats:sub>1A<\/jats:sub>R binding using positron emission tomography (PET). We studied 16 unmedicated symptomatic outpatients with PD and 15 matched healthy controls. Seven patients had an additional diagnosis of a current major depressive episode, however PD was the primary diagnosis. A 120 min PET study of 5-HT<jats:sub>1A<\/jats:sub>R binding was acquired using a GE Advance scanner in three-dimensional mode. Using quantitative PET image analysis, regional values were obtained for [18F]-FCWAY volume of distribution (DV), corrected for plasma protein binding, and K1, the delivery rate of [18F]-FCWAY from plasma to tissue. MRI scanning was performed using a GE Signa Scanner (3.0 Tesla) to provide an anatomical framework for image analysis and partial volume correction of PET data. PD patients showed lower DV in the anterior cingulate (<jats:italic>t<\/jats:italic>= 4.3;<jats:italic>p<\/jats:italic>&lt; 0.001), posterior cingulate (<jats:italic>t<\/jats:italic>= 4.1;<jats:italic>p<\/jats:italic>&lt; 0.001), and raphe (<jats:italic>t<\/jats:italic>= 3.1;<jats:italic>p<\/jats:italic>= 0.004). Comparing patients with PD, patients with PD and comorbid depression, and healthy controls revealed that DVs did not differ between PD patients and PD patients with comorbid depression, whereas both patient groups differed significantly from controls. These results provide for the first time<jats:italic>in vivo<\/jats:italic>evidence for the involvement of 5-HT<jats:sub>1A<\/jats:sub>Rs in the pathophysiology of PD.<\/jats:p>","DOI":"10.1523\/jneurosci.4921-03.2004","type":"journal-article","created":{"date-parts":[[2004,1,21]],"date-time":"2004-01-21T19:33:07Z","timestamp":1074713587000},"page":"589-591","source":"Crossref","is-referenced-by-count":310,"title":["Reduced Serotonin Type 1<sub>A<\/sub>Receptor Binding in Panic Disorder: Figure 1."],"prefix":"10.1523","volume":"24","author":[{"given":"Alexander","family":"Neumeister","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Earle","family":"Bain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison C.","family":"Nugent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Carson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Bonne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Luckenbaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Eckelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Herscovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis S.","family":"Charney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne C.","family":"Drevets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2004,1,21]]},"reference":[{"key":"2023041303045234000_24.3.589.1","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(91)90434-N"},{"key":"2023041303045234000_24.3.589.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(00)00118-9"},{"key":"2023041303045234000_24.3.589.3","unstructured":"Charney DS, Drevets WC (2002) Neurobiological basis of anxiety disorders. In: Neuropsychopharmacology: the fifth generation of progress (Davis KL, Charney DS, Coyle JT, Nemeroff C, eds), pp 901-930. Philadelphia: Lippincott Williams and Wilkins."},{"key":"2023041303045234000_24.3.589.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00189-4"},{"key":"2023041303045234000_24.3.589.5","doi-asserted-by":"crossref","unstructured":"First MB, Gibbon M, Spitzer RL, Williams JBW (1996) Structured clinical interview for DSM-IV axis I disorders: nonpatient edition (SCID-I\/NP). New York: Biometrics Department, New York State Psychiatric Institute.","DOI":"10.1037\/t07827-000"},{"key":"2023041303045234000_24.3.589.6","doi-asserted-by":"publisher","DOI":"10.1038\/416396a"},{"key":"2023041303045234000_24.3.589.7","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.9.929"},{"key":"2023041303045234000_24.3.589.8","doi-asserted-by":"crossref","first-page":"8788","DOI":"10.1523\/JNEUROSCI.23-25-08788.2003","volume":"23","year":"2003","journal-title":"J Neurosci"},{"key":"2023041303045234000_24.3.589.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00224-8"},{"key":"2023041303045234000_24.3.589.10","unstructured":"Maxwell ME (1992) Manual for the family interview for genetic studies (FIGS). In: Clinical neurogenetics branch, intramural research program. National Institute of Mental Health, Bethesda MD."},{"key":"2023041303045234000_24.3.589.11","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"2023041303045234000_24.3.589.12","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/1025389031000111311","volume":"6","year":"2003","journal-title":"Stress"},{"key":"2023041303045234000_24.3.589.13","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1176\/ajp.154.11.1571","volume":"154","year":"1997","journal-title":"Am J Psychiatry"},{"key":"2023041303045234000_24.3.589.14","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1212\/WNL.42.9.1743","volume":"42","year":"1992","journal-title":"Neurology"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.4921-03.2004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T15:52:21Z","timestamp":1681401141000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.4921-03.2004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,21]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2004,1,21]]},"published-print":{"date-parts":[[2004,1,21]]}},"alternative-id":["10.1523\/JNEUROSCI.4921-03.2004"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.4921-03.2004","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1,21]]}}}