{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:22:34Z","timestamp":1790914954795,"version":"4.1.0"},"reference-count":62,"publisher":"Society for Neuroscience","issue":"12","license":[{"start":{"date-parts":[[2006,9,22]],"date-time":"2006-09-22T00:00:00Z","timestamp":1158883200000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2006,3,22]]},"abstract":"<jats:p>To address the hypothesis that retinoids produced by synthesizing enzymes present in the primary olfactory system influence the mouse olfactory sensory map, we expressed a dominant-negative retinoic acid receptor selectively in olfactory sensory neurons. We show that neurons deficient in nuclear retinoid signaling are responsive to odors and form correct odorant receptor-specific axonal projections to target neurons in the olfactory bulb of the brain. Subsequent to the formation of the map, the neurons die prematurely by retrograde-driven caspase-3 activation, which resembles the previously described mechanism of neural death after olfactory bulb ablation. This neurodegenerative event is initiated the second postnatal week and occurs in the adult animal without a compensatory increase of progenitor cell proliferation. In addition, we find that nuclear retinoid signaling is required for the expression of a retinoic acid-degrading enzyme, Cyp26B1, in a small fraction of mature neurons. Collectively, the results provide evidence for a role of locally regulated retinoid metabolism in neuroprotection and in determining population size of neurons at a late stage of neural circuit formation.<\/jats:p>","DOI":"10.1523\/jneurosci.4955-05.2006","type":"journal-article","created":{"date-parts":[[2006,3,22]],"date-time":"2006-03-22T15:18:20Z","timestamp":1143040700000},"page":"3281-3291","source":"Crossref","is-referenced-by-count":48,"title":["Retinoic Acid Receptor-Dependent Survival of Olfactory Sensory Neurons in Postnatal and Adult Mice"],"prefix":"10.1523","volume":"26","author":[{"given":"Maria","family":"H\u00e4gglund","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Berghard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Strotmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staffan","family":"Bohm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2006,3,22]]},"reference":[{"key":"2023041303172558000_26.12.3281.1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00317"},{"key":"2023041303172558000_26.12.3281.2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00441-003-0709-1","volume":"312","year":"(2003)","journal-title":"Cell Tissue Res"},{"key":"2023041303172558000_26.12.3281.3","doi-asserted-by":"publisher","DOI":"10.1002\/neu.10192"},{"key":"2023041303172558000_26.12.3281.4","doi-asserted-by":"crossref","first-page":"9313","DOI":"10.1523\/JNEUROSCI.19-21-09313.1999","volume":"19","year":"(1999)","journal-title":"J Neurosci"},{"key":"2023041303172558000_26.12.3281.5","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1096\/fasebj.10.9.8801176","volume":"10","year":"(1996)","journal-title":"FASEB J"},{"key":"2023041303172558000_26.12.3281.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80654-6"},{"key":"2023041303172558000_26.12.3281.7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00286.x"},{"key":"2023041303172558000_26.12.3281.8","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.1242\/jcs.00169","volume":"115","year":"(2002)","journal-title":"J Cell Sci"},{"key":"2023041303172558000_26.12.3281.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03563.x"},{"key":"2023041303172558000_26.12.3281.10","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20120"},{"key":"2023041303172558000_26.12.3281.11","doi-asserted-by":"crossref","first-page":"7099","DOI":"10.1523\/JNEUROSCI.21-18-07099.2001","volume":"21","year":"(2001)","journal-title":"J Neurosci"},{"key":"2023041303172558000_26.12.3281.12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0306336101"},{"key":"2023041303172558000_26.12.3281.13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.7.2989"},{"key":"2023041303172558000_26.12.3281.14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.21.8565"},{"key":"2023041303172558000_26.12.3281.15","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.mcn.2005.04.011","volume":"29","year":"(2005)","journal-title":"Mol Cell Neurosci"},{"key":"2023041303172558000_26.12.3281.16","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.1523\/JNEUROSCI.21-16-06423.2001","volume":"21","year":"(2001)","journal-title":"J Neurosci"},{"key":"2023041303172558000_26.12.3281.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00467-8"},{"key":"2023041303172558000_26.12.3281.18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.261463298"},{"key":"2023041303172558000_26.12.3281.19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0437937100"},{"key":"2023041303172558000_26.12.3281.20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01206454","volume":"8","year":"(1979)","journal-title":"J Neurocytol"},{"key":"2023041303172558000_26.12.3281.21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0165-3806(99)00014-0","volume":"114","year":"(1999)","journal-title":"Brain Res Dev Brain Res"},{"key":"2023041303172558000_26.12.3281.22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.molbrainres.2004.08.003","volume":"132","year":"(2004)","journal-title":"Brain Res Mol Brain Res"},{"key":"2023041303172558000_26.12.3281.23","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1128\/MCB.19.5.3372","volume":"19","year":"(1999)","journal-title":"Mol Cell Biol"},{"key":"2023041303172558000_26.12.3281.24","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00342-X"},{"key":"2023041303172558000_26.12.3281.25","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00121-5"},{"key":"2023041303172558000_26.12.3281.26","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600757"},{"key":"2023041303172558000_26.12.3281.27","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.54.8"},{"key":"2023041303172558000_26.12.3281.28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7696(01)09010-6","volume":"209","year":"(2001)","journal-title":"Int Rev Cytol"},{"key":"2023041303172558000_26.12.3281.29","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00481-X"},{"key":"2023041303172558000_26.12.3281.30","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(99)00132-X"},{"key":"2023041303172558000_26.12.3281.31","doi-asserted-by":"publisher","DOI":"10.1023\/B:APPT.0000018793.10779.dc"},{"key":"2023041303172558000_26.12.3281.32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191369798"},{"key":"2023041303172558000_26.12.3281.33","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81387-2"},{"key":"2023041303172558000_26.12.3281.34","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02998.x"},{"key":"2023041303172558000_26.12.3281.35","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00561-5"},{"key":"2023041303172558000_26.12.3281.36","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2001.1019"},{"key":"2023041303172558000_26.12.3281.37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03159.x"},{"key":"2023041303172558000_26.12.3281.38","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1138"},{"key":"2023041303172558000_26.12.3281.39","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1177\/153537020222600809","volume":"226","year":"(2001)","journal-title":"Exp Biol Med (Maywood)"},{"key":"2023041303172558000_26.12.3281.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2005.06.019"},{"key":"2023041303172558000_26.12.3281.41","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90015-9"},{"key":"2023041303172558000_26.12.3281.42","doi-asserted-by":"publisher","DOI":"10.1101\/gad.5.8.1333"},{"key":"2023041303172558000_26.12.3281.43","doi-asserted-by":"publisher","DOI":"10.1007\/BF00267823"},{"key":"2023041303172558000_26.12.3281.44","doi-asserted-by":"publisher","DOI":"10.1002\/ar.10047"},{"key":"2023041303172558000_26.12.3281.45","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00532-4"},{"key":"2023041303172558000_26.12.3281.46","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2588-04.2004"},{"key":"2023041303172558000_26.12.3281.47","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90170-1"},{"key":"2023041303172558000_26.12.3281.48","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10369"},{"key":"2023041303172558000_26.12.3281.49","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90029-9"},{"key":"2023041303172558000_26.12.3281.50","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3073-04.2005"},{"key":"2023041303172558000_26.12.3281.51","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/12.12.1244"},{"key":"2023041303172558000_26.12.3281.52","doi-asserted-by":"publisher","DOI":"10.1101\/gad.276003"},{"key":"2023041303172558000_26.12.3281.53","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01867"},{"key":"2023041303172558000_26.12.3281.54","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(04)00075-3"},{"key":"2023041303172558000_26.12.3281.55","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1523\/JNEUROSCI.17-10-03610.1997","volume":"17","year":"(1997)","journal-title":"J Neurosci"},{"key":"2023041303172558000_26.12.3281.56","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200211117"},{"key":"2023041303172558000_26.12.3281.57","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19980518)394:4<445::AID-CNE4>3.0.CO;2-1"},{"key":"2023041303172558000_26.12.3281.58","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(04)00224-7"},{"key":"2023041303172558000_26.12.3281.59","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00444.x"},{"key":"2023041303172558000_26.12.3281.60","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1006\/bbrc.1999.0320","volume":"256","year":"(1999)","journal-title":"Biochem Biophys Res Commun"},{"key":"2023041303172558000_26.12.3281.61","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00262-8"},{"key":"2023041303172558000_26.12.3281.62","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093468"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.4955-05.2006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T13:18:52Z","timestamp":1681391932000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.4955-05.2006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,22]]},"references-count":62,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2006,3,22]]},"published-print":{"date-parts":[[2006,3,22]]}},"alternative-id":["10.1523\/JNEUROSCI.4955-05.2006"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.4955-05.2006","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,22]]}}}