{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:25:51Z","timestamp":1792725951243,"version":"4.5.0"},"reference-count":59,"publisher":"Society for Neuroscience","issue":"15","license":[{"start":{"date-parts":[[2006,10,12]],"date-time":"2006-10-12T00:00:00Z","timestamp":1160611200000},"content-version":"vor","delay-in-days":183,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2006,4,12]]},"abstract":"<jats:p>\n                    Dysfunction of the 140 aa protein \u03b1-synuclein plays a central role in Lewy body disorders, including Parkinson\u2019s disease, as well as in multiple system atrophy. Here, we show that the expression of truncated human \u03b1-synuclein(1\u2013120), driven by the rat tyrosine hydroxylase promoter on a mouse \u03b1-synuclein null background, leads to the formation of pathological inclusions in the substantia nigra and olfactory bulb and to a reduction in striatal dopamine levels. At the behavioral level, the transgenic mice showed a progressive reduction in spontaneous locomotion and an increased response to amphetamine. These findings suggest that the C-terminal of \u03b1-synuclein is an important regulator of aggregation\n                    <jats:italic>in vivo<\/jats:italic>\n                    and will help to understand the mechanisms underlying the pathogenesis of Lewy body disorders and multiple system atrophy.\n                  <\/jats:p>","DOI":"10.1523\/jneurosci.4965-05.2006","type":"journal-article","created":{"date-parts":[[2006,4,12]],"date-time":"2006-04-12T12:52:49Z","timestamp":1144846369000},"page":"3942-3950","source":"Crossref","is-referenced-by-count":303,"title":["Pathological Changes in Dopaminergic Nerve Cells of the Substantia Nigra and Olfactory Bulb in Mice Transgenic for Truncated Human \u03b1-Synuclein(1\u2013120): Implications for Lewy Body Disorders"],"prefix":"10.1523","volume":"26","author":[{"given":"George K.","family":"Tofaris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Garcia 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